EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.8 | 0.0065 | - |
5-phospho-alpha-D-ribose 1-diphosphate | with guanine as cosubstrate, at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 0.01 | - |
guanine | at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 0.0141 | - |
5-phospho-alpha-D-ribose 1-diphosphate | with hypoxanthine as cosubstrate, at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 0.026 | - |
hypoxanthine | at pH 7.5 and 25°C | Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.8 | Mg2+ | required for activity | Mycobacterium tuberculosis |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.2.8 | 22251 | - |
2 * 22251, calculated from amino acid sequence | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.8 | guanine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | - |
GMP + diphosphate | - |
? | |
2.4.2.8 | hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | - |
IMP + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.8 | Mycobacterium tuberculosis | P9WHQ9 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.8 | - |
Mycobacterium tuberculosis |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.8 | guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | GMP + diphosphate | - |
? | |
2.4.2.8 | hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | IMP + diphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.2.8 | homodimer | 2 * 22251, calculated from amino acid sequence | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.8 | HGPRT | - |
Mycobacterium tuberculosis |
2.4.2.8 | hypoxanthine-guanine phosphoribosyltransferase | - |
Mycobacterium tuberculosis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.8 | 0.193 | - |
guanine | at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 0.89 | - |
hypoxanthine | at pH 7.5 and 25°C | Mycobacterium tuberculosis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.2.8 | 0.29 | - |
5-phospho-alpha-D-ribose 1-diphosphate | with guanine as cosubstrate, at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 0.63 | - |
5-phospho-alpha-D-ribose 1-diphosphate | with hypoxanthine as cosubstrate, at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 19 | - |
guanine | at pH 7.5 and 25°C | Mycobacterium tuberculosis | |
2.4.2.8 | 34 | - |
hypoxanthine | at pH 7.5 and 25°C | Mycobacterium tuberculosis |