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Literature summary extracted from

  • Garoby-Salom, S.; Rouahi, M.; Mucher, E.; Auge, N.; Salvayre, R.; Negre-Salvayre, A.
    Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL (2015), Redox Biol., 4, 118-126.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.212 gene has2, quantitative real time PCR enzyme expression analysis, HAS2 expression is dependent on ceramide generated by neutral type 2 sphingomyelinase, nSMase2, as shown by treatment with C2-ceramide that decreases HAS2 expression in murine fro/fro fibroblasts Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.212 ceramide
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.212 Mus musculus P70312 isozyme HAS2, gene has2
-
2.4.1.212 Mus musculus 129/Sv P70312 isozyme HAS2, gene has2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.212 fibroblast
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.212 Has2
-
 Mus musculus
2.4.1.212 hyaluronan synthase-2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.1.212 physiological function recombinant hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by human oxidized LDL. Resistance of fro/fro cells to starvation-induced apoptosis is associated with an increased expression of hyaluronan synthase 2 (HAS2) mRNAs and protein, which is inhibited by ceramide. The protective mechanism of HAS2 involves an increased expression of the heat-shock protein Hsp72, a chaperone with antiapoptotic activity. Antiapoptotic properties of HAS2 , overview Mus musculus