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Literature summary extracted from

  • Xu, I.M.; Lai, R.K.; Lin, S.H.; Tse, A.P.; Chiu, D.K.; Koh, H.Y.; Law, C.T.; Wong, C.M.; Cai, Z.; Wong, C.C.; Ng, I.O.
    Transketolase counteracts oxidative stress to drive cancer development (2016), Proc. Natl. Acad. Sci. USA, 113, 725-734.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.2.1.1 medicine enzyme inhibition sensitizes cancer cells to sorafenib treatment Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate Homo sapiens
-
 D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.2.1.1 hepatocellular carcinoma cell
-
 Homo sapiens
-
2.2.1.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.1 sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate
-
 Homo sapiens D-ribose 5-phosphate + D-xylulose 5-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.2.1.1 TKT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.2.1.1 Homo sapiens enzyme overexpression in cancer cells is a response of Nuclear Factor, Erythroid 2-Like 2 activation up

General Information

EC Number General Information Comment Organism
2.2.1.1 malfunction enzyme knockdown suppresses HCC cell proliferation by inducing reactive eoxygen species accumulation and reactive oxygen species-associated cell-cycle delay Homo sapiens
2.2.1.1 physiological function the enzyme is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. Overexpression of the enzyme is also closely associated with aggressive clinicopathological hepatocellular carcinoma cell features, including the presence of venous invasion and tumor microsatellite formation, increased tumor size, and absence of tumor encapsulation Homo sapiens