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Literature summary extracted from

  • Blaskovich, M.A.; Yendluri, V.; Lawrence, H.R.; Lawrence, N.J.; Sebti, S.M.; Springett, G.M.
    Lysophosphatidic acid acyltransferase beta regulates mTOR signaling (2013), PLoS ONE, 8, e78632.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.51 oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol Homo sapiens
-
 CoA + 1,2-dioleoyl-sn-phosphatidylinositol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 AsPC-1 cell
-
 Homo sapiens
-
2.3.1.51 MiaPaCa-2 cell
-
 Homo sapiens
-
2.3.1.51 PANC-1 cell
-
 Homo sapiens
-
2.3.1.51 pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol
-
 Homo sapiens CoA + 1,2-dioleoyl-sn-phosphatidylinositol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.51 LPAAT-beta
-
 Homo sapiens
2.3.1.51 lysophosphatidic acid acyltransferase beta
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.51 malfunction enzyme knockdown inhibits proliferation and anchorage-independent growth of pancreatic cancer cells Homo sapiens
2.3.1.51 physiological function the enzyme regulates mTOR signaling by affecting its association with FKBP38 and regulates nuclear shape and Lipin 1 nuclear localization Homo sapiens