Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhang, Q.; Cao, Y.F.; Ran, R.X.; Li, R.S.; Wu, X.; Dong, P.P.; Zhang, Y.Y.; Hu, C.M.; Wang, W.M.
    Strong specific inhibition of UDP-glucuronosyltransferase 2B7 by atractylenolide I and III (2016), Phytother. Res., 30, 25-30.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.17 (4aS,8aR,9aS)-9a-hydroxy-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(4H)-one i.e. atractylenolide II, one of two important efficient herbal ingredients isolated from Atractylodes macrocepha exhibits specific inhibition towards UGT2B7, with negligible influence towards other UGT isoforms Homo sapiens
2.4.1.17 (8aS)-3,8a-dimethyl-5-methylidene-4a,5,6,7,8,8a-hexahydronaphtho[2,3-b]furan-2(4H)-one i.e. atractylenolide I, one of two important efficient herbal ingredients isolated from Atractylodes macrocephala, exhibits specific competitive inhibition towards UGT2B7, with negligible influence towards other UGT isoforms Homo sapiens
2.4.1.17 additional information in silico docking and molecular homology modeling for inhibition mechanism elucidation. Atractylenolide I exerts stronger inhibition potential than atractylenolide III towards UGT2B7, which is attributed to the different hydrogen bonds and hydrophobic interactions. Inhibition kinetic analysis for the inhibition of atractylenolide I towards UGT2B7 reveals competitive inhibition by atractylenolide I Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+ required Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P16662
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + 4-methylumbelliferyl-beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase 2B7
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.4
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.17 additional information
-
 additional information inhibition kinetic analysis Homo sapiens