EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.47 | agriculture | 8-amino-7-oxononanoate synthase triazolyl phenyl disulfide inhibitors as potential herbicides, overview | Arabidopsis thaliana |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.47 | gene bioF, recombinant expression of the enzyme in Escherichia coli strain BL21-Gold (DE) | Arabidopsis thaliana |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.47 | 3-([4-[(2-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | 3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | 3-([4-[(3,5-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | 3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | 3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | 3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide | - |
Arabidopsis thaliana | |
2.3.1.47 | additional information | triazolyl phenyl disulfides as 8-amino-7-oxononanoate synthase inhibitors, overview | Arabidopsis thaliana | |
2.3.1.47 | N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide | i.e. KHG23844, induces 2.3fold higher L-alanine accumulation in the treated Arabidopsis thaliana plants. 45-day old Arabidopsis thaliana plants are completely killed by the compound. Foliar supplement of 1 mM biotin at 1 and 2 days before KHG23844 application effectively recovers the growth inhibition of plants treated with the inhibitor | Arabidopsis thaliana |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.47 | pimeloyl-[acyl-carrier protein] + L-alanine | Arabidopsis thaliana | - |
8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein] | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.47 | Arabidopsis thaliana | Q8GW43 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.47 | recombinant enzyme from Escherichia coli strain BL21-Gold (DE) | Arabidopsis thaliana |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.47 | leaf | - |
Arabidopsis thaliana | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.47 | pimeloyl-[acyl-carrier protein] + L-alanine | - |
Arabidopsis thaliana | 8-amino-7-oxononanoate + CO2 + holo-[acyl-carrier protein] | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.47 | 7-keto-8-aminopelargonate synthase | - |
Arabidopsis thaliana |
2.3.1.47 | AONS | - |
Arabidopsis thaliana |
2.3.1.47 | KAPAS | - |
Arabidopsis thaliana |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.47 | 30 | - |
assay at | Arabidopsis thaliana |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.47 | 7.5 | - |
assay at | Arabidopsis thaliana |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.47 | 0.037 | - |
pH 7.5, 30°C, recombinant enzyme | Arabidopsis thaliana | 3-[[4-(benzylamino)phenyl]disulfanyl]-1H-1,2,4-triazole-1-carboxamide | |
2.3.1.47 | 0.055 | - |
pH 7.5, 30°C, recombinant enzyme | Arabidopsis thaliana | 3-([4-[(3,4-difluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | |
2.3.1.47 | 0.063 | - |
pH 7.5, 30°C, recombinant enzyme | Arabidopsis thaliana | N-(2-fluorophenyl)-3-(phenyldisulphanyl)-1H-1,2,4-triazole-1-carboxamide | |
2.3.1.47 | 0.07 | - |
pH 7.5, 30°C, recombinant enzyme | Arabidopsis thaliana | 3-([4-[(4-nitrophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide | |
2.3.1.47 | 0.073 | - |
pH 7.5, 30°C, recombinant enzyme | Arabidopsis thaliana | 3-([4-[(4-fluorophenyl)amino]phenyl]disulfanyl)-1H-1,2,4-triazole-1-carboxamide |