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Literature summary extracted from

  • Fuellgrabe, J.; Lynch-Day, M.A.; Heldring, N.; Li, W.; Struijk, R.B.; Ma, Q.; Hermanson, O.; Rosenfeld, M.G.; Klionsky, D.J.; Joseph, B.
    The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy (2013), Nature, 500, 468-471.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 Homo sapiens acetylation of Lys16 CoA + acetylhistone H4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens Q9H7Z6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 HeLa cell
-
 Homo sapiens
-
2.3.1.48 U-1810 cell
-
 Homo sapiens
-
2.3.1.48 U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone H4 acetylation of Lys16 Homo sapiens CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 histone H4 lysine 16 acetyltransferase
-
 Homo sapiens
2.3.1.48 hMOF
-
 Homo sapiens
2.3.1.48 KAT8
-
 Homo sapiens
2.3.1.48 MYST1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.48 acetyl-CoA
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.48 malfunction antagonizing H4K16ac downregulation upon autophagy induction results in the promotion of cell death Homo sapiens
2.3.1.48 metabolism alteration in the specific histone post-translational modification during autophagy affects the transcriptional regulation of autophagy-related genes and initiates a regulatory feedback loop,which serves as a key determinant of survival versus death responses upon autophagy induction Homo sapiens
2.3.1.48 physiological function autophagy is an evolutionarily conserved catabolic process involved in several physiological and pathological processes. Although primarily cytoprotective, autophagy can also contribute to cell death. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy. Induction of autophagy by rapamycin is coupled to reduction of histone H4 lysine 16 acetylation through downregulation of the histone acetyltransferase hMOF Homo sapiens