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Literature summary extracted from

  • Jacques, I.; Moutiez, M.; Witwinowski, J.; Darbon, E.; Martel, C.; Seguin, J.; Favry, E.; Thai, R.; Lecoq, A.; Dubois, S.; Pernodet, J.; Gondry, M.; Belin, P.
    Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity (2015), Nat. Chem. Biol., 11, 721-727.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe Streptomyces albulus highest activity tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe Bacillus sp. NSP9.1 second best activity tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe Bacillus sp. 171095_106 second best activity tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet Streptomyces albulus lowest activity tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet Bacillus sp. NSP9.1 lowest activity tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet Bacillus sp. 171095_106 lowest activity tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe Bacillus sp. NSP9.1 highest activity 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe Bacillus sp. 171095_106 highest activity 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe Streptomyces albulus second best activity 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr Streptomyces albulus
-
 tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.20 Bacillus sp. 171095_106
-
-
-
2.3.2.20 Bacillus sp. NSP9.1
-
-
-
2.3.2.20 Streptomyces albulus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe highest activity Streptomyces albulus tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe second best activity Bacillus sp. NSP9.1 tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe second best activity Bacillus sp. 171095_106 tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet lowest activity Streptomyces albulus tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet lowest activity Bacillus sp. NSP9.1 tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet lowest activity Bacillus sp. 171095_106 tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe highest activity Bacillus sp. NSP9.1 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe highest activity Bacillus sp. 171095_106 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe second best activity Streptomyces albulus 2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)
-
 ?
2.3.2.20 L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr
-
 Streptomyces albulus tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.20 CDPS
-
 Streptomyces albulus
2.3.2.20 CDPS
-
 Bacillus sp. NSP9.1
2.3.2.20 CDPS
-
 Bacillus sp. 171095_106
2.3.2.20 cyclodipeptide synthase
-
 Streptomyces albulus
2.3.2.20 cyclodipeptide synthase
-
 Bacillus sp. NSP9.1
2.3.2.20 cyclodipeptide synthase
-
 Bacillus sp. 171095_106