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Literature summary extracted from

  • Kalebic, N.; Martinez, C.; Perlas, E.; Hublitz, P.; Bilbao-Cortes, D.; Fiedorczuk, K.; Andolfo, A.; Heppenstall, P.A.
    Tubulin acetyltransferase alphaTAT1 destabilizes microtubules independently of its acetylation activity (2013), Mol. Cell. Biol., 33, 1114-1123.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.108
-
 Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.108 G134W/G136W/L139P loss of catalytic activity Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.108 microtubule colocalization with microtubules Mus musculus 5874
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.108 Mus musculus Q8K341
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.108 acetylation enzyme catalyzes acetylation of multiple lysine residues on itself. Autoacetylation of alphaTAT1 increases its catalytic activity at microtubules Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.108 cerebellum
-
 Mus musculus
-
2.3.1.108 ganglion dorsal root ganglion Mus musculus
-
2.3.1.108 hippocampus
-
 Mus musculus
-
2.3.1.108 nervous system strongest expression in nervous systems of embryonic and adult mice Mus musculus
-
2.3.1.108 spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.108 acetyl-CoA + [alpha-TAT1]-L-lysine
-
 Mus musculus CoA + [alpha-TAT1]-N6-acetyl-L-lysine enzyme TAT1 acetylates itself in a regulatory mechanism that is required for effective modification of tubulin. Acetylation of multiple lysine residues on itself ?
2.3.1.108 acetyl-CoA + [alpha-tubulin]-L-lysine40
-
 Mus musculus CoA + [alpha-tubulin]-N6-acetyl-L-lysine40
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.108 alphaTAT1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.3.1.108 physiological function alphaTAT1 promotes microtubule destabilization and accelerates microtubule dynamics. This effect persists in an alphaTAT1 mutant with no acetyltransferase activity, suggesting that interaction of alphaTAT1 with microtubules is the critical factor regulating microtubule stability Mus musculus