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Literature summary extracted from

  • Overwin, H.; Wray, V.; Hofer, B.
    Biotransformation of phloretin by amylosucrase yields three novel dihydrochalcone glucosides (2015), J. Biotechnol., 211, 103-106.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.4 synthesis the enzyme might be useful for important tailoring reactions for the generation of bioactive compounds by glycosylation Neisseria polysaccharea

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.4 sucrose + phloretin Neisseria polysaccharea the enzyme is a non-Leloir glycosyltransferase that catalyzes the stereospecific glucosylation of phloretin at the 4'-position. Phloretin and its glucosylation derivatives are cytotoic, overview D-fructose + phloretin glucoside A1 + phloretin glucoside A2 + phloretin glucoside A3 three major phloretin-dependent sugar-positive products are observed containing one to three Glc residues (Phlo-A1, -A2, -A3), identification by TLC and NMR spectrometry. In all three metabolites the first Glc, GlcA, is linked to the aglycone at C4' ?
2.4.1.4 sucrose + phloretin Neisseria polysaccharea ATCC 43768 the enzyme is a non-Leloir glycosyltransferase that catalyzes the stereospecific glucosylation of phloretin at the 4'-position. Phloretin and its glucosylation derivatives are cytotoic, overview D-fructose + phloretin glucoside A1 + phloretin glucoside A2 + phloretin glucoside A3 three major phloretin-dependent sugar-positive products are observed containing one to three Glc residues (Phlo-A1, -A2, -A3), identification by TLC and NMR spectrometry. In all three metabolites the first Glc, GlcA, is linked to the aglycone at C4' ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.4 Neisseria polysaccharea Q9ZEU2
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-
2.4.1.4 Neisseria polysaccharea ATCC 43768 Q9ZEU2
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.4 sucrose + phloretin the enzyme is a non-Leloir glycosyltransferase that catalyzes the stereospecific glucosylation of phloretin at the 4'-position. Phloretin and its glucosylation derivatives are cytotoic, overview Neisseria polysaccharea D-fructose + phloretin glucoside A1 + phloretin glucoside A2 + phloretin glucoside A3 three major phloretin-dependent sugar-positive products are observed containing one to three Glc residues (Phlo-A1, -A2, -A3), identification by TLC and NMR spectrometry. In all three metabolites the first Glc, GlcA, is linked to the aglycone at C4' ?
2.4.1.4 sucrose + phloretin the enzyme is a non-Leloir glycosyltransferase that catalyzes the stereospecific glucosylation of phloretin at the 4'-position. Phloretin and its glucosylation derivatives are cytotoic, overview Neisseria polysaccharea ATCC 43768 D-fructose + phloretin glucoside A1 + phloretin glucoside A2 + phloretin glucoside A3 three major phloretin-dependent sugar-positive products are observed containing one to three Glc residues (Phlo-A1, -A2, -A3), identification by TLC and NMR spectrometry. In all three metabolites the first Glc, GlcA, is linked to the aglycone at C4' ?
2.4.1.4 sucrose + phloretin the enzyme catalyzes the stereospecific glucosylation of phloretin at the 4'-position Neisseria polysaccharea D-fructose + phloretin glucoside 1 + phloretin glucoside 2 + phloretin glucoside 3
-
 ?
2.4.1.4 sucrose + phloretin the enzyme catalyzes the stereospecific glucosylation of phloretin at the 4'-position Neisseria polysaccharea ATCC 43768 D-fructose + phloretin glucoside 1 + phloretin glucoside 2 + phloretin glucoside 3
-
 ?