EC Number | Application | Comment | Organism |
---|---|---|---|
2.4.1.277 | synthesis | expression of different deoxysugar biosynthetic gene cassettes and the gene encoding a substrate-flexible glycosyltransferase DesVII in Streptomyces venezuelae YJ003 mutant strain bearing a deletion of a desosamine biosynthetic (des) gene cluster. The resulting recombinants produce macrolide antibiotic YC-17 analogs possessing unnatural sugars replacing native D-desosamine. These metabolites are D-quinovosyl-10-deoxymethynolide, L-rhamnosyl-10-deoxymethynolide, L-olivosyl-10-deoxymethynolide, and D-boivinosyl-10-deoxymethynolide | Streptomyces venezuelae |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.277 | Streptomyces venezuelae | Q9ZGH7 | - |
- |
2.4.1.277 | Streptomyces venezuelae ATCC 15439 | Q9ZGH7 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.277 | dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + 10-deoxymethymycin | - |
? | |
2.4.1.277 | dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + 10-deoxymethymycin | - |
? | |
2.4.1.277 | dTDP-D-boivinose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + D-boivinosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-D-boivinose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + D-boivinosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-D-quinovose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + D-quinovosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-D-quinovose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + D-quinovosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-L-olivose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + L-olivosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-L-olivose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + L-olivosyl-10-deoxymethynolide | - |
? | |
2.4.1.277 | dTDP-L-rhamnose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + L-rhamnosyl-10-deoxymethynolide | substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin | ? | |
2.4.1.277 | dTDP-L-rhamnose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + L-rhamnosyl-10-deoxymethynolide | substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin | ? |