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Literature summary extracted from

  • Batool, S.; Nawaz, M.S.; Kamal, M.A.
    In silico analysis of the amido phosphoribosyltransferase inhibition by PY873, PY899 and a derivative of isophthalic acid (2013), Invest. New Drugs, 31, 1355-1363.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.14 2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine PY873 Homo sapiens
2.4.2.14 2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline PY899 Homo sapiens
2.4.2.14 5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)isophthalic acid
-
 Homo sapiens
2.4.2.14 AMP
-
 Homo sapiens
2.4.2.14 cAMP competitive inhibitor Homo sapiens
2.4.2.14 cGMP competitive inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate Homo sapiens
-
 L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.14 Homo sapiens Q06203
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.14 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate
-
 Homo sapiens L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.14 amido phosphoribosyltransferase
-
 Homo sapiens
2.4.2.14 APRT
-
 Homo sapiens
2.4.2.14 glutamine phosphoribosylpyrophosphate amidotransferase
-
 Homo sapiens
2.4.2.14 GPAT
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.14 0.00131
-
 AMP pH and temperature not specified in the publication Homo sapiens
2.4.2.14 0.00331
-
 2,4-diamino-6-(3,4,5-trimethoxybenzyl)-5,6,7,8-tetrahydro-quinazoline pH and temperature not specified in the publication Homo sapiens
2.4.2.14 0.02327
-
 2,4-diamino-6-(3,4,5-trimethoxyanilino)-methylpyrido[3,2-d]pyrimidine pH and temperature not specified in the publication Homo sapiens
2.4.2.14 0.1167
-
 5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)isophthalic acid pH and temperature not specified in the publication Homo sapiens