BRENDA - Enzyme Database

Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes

Wang, C.; Yang, X.; Wang, E.; Li, B.; Int. J. Quantum Chem. 113, 1409-1415 (2013)
No PubMed abstract available

Data extracted from this reference:

KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.192
additional information
-
additional information
energy profile and thermodynamics, overview
Staphylococcus aureus
2.1.1.224
additional information
-
additional information
energy profile and thermodynamics, overview
Staphylococcus aureus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
Staphylococcus aureus
-
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
?
2.1.1.192
additional information
Staphylococcus aureus
methylation at C2 is similar to that at C8, cf. EC 2.1.1.224
?
-
-
-
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
Staphylococcus aureus
-
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
?
2.1.1.224
additional information
Staphylococcus aureus
methylation at C8 is similar to that at C2, cf. EC 2.1.1.192
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.192
Staphylococcus aureus
-
-
-
2.1.1.224
Staphylococcus aureus
A5HBL2
-
-
Reaction
EC Number
Reaction
Commentary
Organism
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
reaction mechanism modeling, overview
Staphylococcus aureus
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
reaction mechanism modeling overview
Staphylococcus aureus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
-
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
-
?
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
-
?
2.1.1.192
additional information
methylation at C2 is similar to that at C8, cf. EC 2.1.1.224
736280
Staphylococcus aureus
?
-
-
-
-
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
-
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
-
?
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
-
?
2.1.1.224
additional information
methylation at C8 is similar to that at C2, cf. EC 2.1.1.192
736280
Staphylococcus aureus
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.192
Ferredoxin
-
Staphylococcus aureus
2.1.1.192
S-adenosyl-L-methionine
dependent on
Staphylococcus aureus
2.1.1.224
Ferredoxin
-
Staphylococcus aureus
2.1.1.224
S-adenosyl-L-methionine
dependent on
Staphylococcus aureus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.192
Ferredoxin
-
Staphylococcus aureus
2.1.1.192
S-adenosyl-L-methionine
dependent on
Staphylococcus aureus
2.1.1.224
Ferredoxin
-
Staphylococcus aureus
2.1.1.224
S-adenosyl-L-methionine
dependent on
Staphylococcus aureus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.1.1.192
additional information
-
additional information
energy profile and thermodynamics, overview
Staphylococcus aureus
2.1.1.224
additional information
-
additional information
energy profile and thermodynamics, overview
Staphylococcus aureus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
Staphylococcus aureus
-
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
?
2.1.1.192
additional information
Staphylococcus aureus
methylation at C2 is similar to that at C8, cf. EC 2.1.1.224
?
-
-
-
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
Staphylococcus aureus
-
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
?
2.1.1.224
additional information
Staphylococcus aureus
methylation at C8 is similar to that at C2, cf. EC 2.1.1.192
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
-
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
-
?
2.1.1.192
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin
two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin
-
-
-
?
2.1.1.192
additional information
methylation at C2 is similar to that at C8, cf. EC 2.1.1.224
736280
Staphylococcus aureus
?
-
-
-
-
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
-
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
-
?
2.1.1.224
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl
736280
Staphylococcus aureus
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
-
-
-
?
2.1.1.224
additional information
methylation at C8 is similar to that at C2, cf. EC 2.1.1.192
736280
Staphylococcus aureus
?
-
-
-
-