Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Badenhorst, C.P.; van der Sluis, R.; Erasmus, E.; van Dijk, A.A.
    Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation (2013), Expert. Opin. Drug Metab. Toxicol., 9, 1139-1153.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.13 E226Q active site mutant Homo sapiens
2.3.1.13 F168L the variant has a lower relative activity than the wild type enzyme Homo sapiens
2.3.1.13 K16N the variant has a greater relative activity than the wild type enzyme Homo sapiens
2.3.1.13 N156S the variant has a greater relative activity than the wild type enzyme Homo sapiens
2.3.1.13 R131H the variant has a greater relative activity than the wild type enzyme Homo sapiens
2.3.1.13 R199C the variant has a lower relative activity than the wild type enzyme Homo sapiens
2.3.1.13 S17T the variant has a lower relative activity than the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.13 acyl-CoA + glycine Homo sapiens
-
 CoA + N-acylglycine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.13 Homo sapiens Q6IB77
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.13 hepatocellular carcinoma cell
-
 Homo sapiens
-
2.3.1.13 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.13 acyl-CoA + glycine
-
 Homo sapiens CoA + N-acylglycine
-
 ?
2.3.1.13 benzoyl-CoA + glycine
-
 Homo sapiens CoA + N-benzoylglycine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.13 monomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.13 GlyAT
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.13 metabolism the enzyme activity affects mitochondrial ATP production, glycine availability, free coenzyme A availability, and the toxicity of various organic acids Homo sapiens
2.3.1.13 physiological function the enzyme plays a role in liver cancer and musculoskeletal development Homo sapiens