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Literature summary extracted from

  • Carradori, S.; Rotili, D.; De Monte, C.; Lenoci, A.; D'Ascenzio, M.; Rodriguez, V.; Filetici, P.; Miceli, M.; Nebbioso, A.; Altucci, L.; Secci, D.; Mai, A.
    Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies (2014), Eur. J. Med. Chem., 80, 569-578.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 1-(4-(3-nitrophenyl)thiazol-2-yl)-2-(propan-2-ylidene)hydrazine
-
 Homo sapiens
2.3.1.48 2-(2-cyclopentylidenehydrazinyl)-4-(3-methoxyphenyl)-1,3-thiazole
-
 Homo sapiens
2.3.1.48 2-(2-cyclopentylidenehydrazinyl)-4-(3-nitrophenyl)-1,3-thiazole
-
 Homo sapiens
2.3.1.48 2-(2-cyclopentylidenehydrazinyl)-4-(4-fluorophenyl)-1,3-thiazole
-
 Homo sapiens
2.3.1.48 2-(2-cyclopentylidenehydrazinyl)-4-(4-methoxyphenyl)-1,3-thiazole
-
 Homo sapiens
2.3.1.48 2-(2-cyclopentylidenehydrazinyl)-4-phenyl-1,3-thiazole
-
 Homo sapiens
2.3.1.48 2-[(1E)-1-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]ethyl]pyridine
-
 Homo sapiens
2.3.1.48 3-[(1E)-1-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]ethyl]-2H-1-benzopyran-2-one
-
 Homo sapiens
2.3.1.48 3-[(E)-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]-2,3-dihydro-1H-indole
-
 Homo sapiens
2.3.1.48 3-[2-[(2Z)-2-(3-methylcyclopentylidene)hydrazinyl]-1,3-thiazol-4-yl]-2H-1-benzopyran-2-one
-
 Homo sapiens
2.3.1.48 3-[2-[2-(propan-2-ylidene)hydrazinyl]-1,3-thiazol-4-yl]-2H-1-benzopyran-2-one
-
 Homo sapiens
2.3.1.48 4-(4-bromophenyl)-2-[2-(propan-2-ylidene)hydrazinyl]-1,3-thiazole
-
 Homo sapiens
2.3.1.48 4-(4-chlorophenyl)-2-[(2E)-2-[1-(1,3-thiazol-2-yl)ethylidene]hydrazinyl]-1,3-thiazole
-
 Homo sapiens
2.3.1.48 4-(4-chlorophenyl)-2-[2-(propan-2-ylidene)hydrazinyl]-1,3-thiazole
-
 Homo sapiens
2.3.1.48 6-(4-chlorophenyl)-2-(2-(3-methylcyclopentylidene)hydrazinyl)pyrimidin-4(3H)-one
-
 Homo sapiens
2.3.1.48 6-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)pyrimidin-4(3H)-one
-
 Homo sapiens
2.3.1.48 anarcadic acid
-
 Homo sapiens
2.3.1.48 C646
-
 Homo sapiens
2.3.1.48 curcumin unspecific Homo sapiens
2.3.1.48 garcinol
-
 Homo sapiens
2.3.1.48 additional information some (thiazol-2-yl)hydrazones act as antiprotozoal, antifungal and anti-MAO agents and as well as Gcn5 HAT inhibitors Homo sapiens
2.3.1.48 Plumbagin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Homo sapiens Q92830
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 HCT-116 cell
-
 Homo sapiens
-
2.3.1.48 U-937 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 Gcn5 HAT
-
 Homo sapiens
2.3.1.48 p300
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.48 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 8
-
 assay at Homo sapiens