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Literature summary extracted from

  • Ohtawa, M.; Yamazaki, H.; Ohte, S.; Matsuda, D.; Ohshiro, T.; Rudel, L.L.; Omura, S.; Tomoda, H.; Nagamitsu, T.
    Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3 (2013), Bioorg. Med. Chem. Lett., 23, 3798-3801.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 (3S,4aR,6S,6aS,12R,12aS,12bS)-3-(acetyloxy)-4-[(acetyloxy)methyl]-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-6-yl 4-cyanobenzoate
-
 Homo sapiens
2.3.1.26 additional information synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors, overview; synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase inhibitors, overview Homo sapiens
2.3.1.26 pyripyropene A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Homo sapiens O75908 ACAT2
-
2.3.1.26 Homo sapiens P35610 ACAT1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.26 ACAT1
-
 Homo sapiens
2.3.1.26 ACAT2
-
 Homo sapiens
2.3.1.26 acyl-CoA:cholesterol acyltransferase 1
-
 Homo sapiens
2.3.1.26 acyl-CoA:cholesterol acyltransferase 2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.26 0.000006
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0000066
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0000068
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.000007
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.0000072
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0000078
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.000009
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
2.3.1.26 0.0000097
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.00001
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
2.3.1.26 0.0000118
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.000013
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
2.3.1.26 0.000014
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
2.3.1.26 0.0000151
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.000019
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
2.3.1.26 0.000023
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.0000232
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.00003
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
2.3.1.26 0.00003
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
2.3.1.26 0.00003
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
2.3.1.26 0.0000368
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0000476
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.00005
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
2.3.1.26 0.00006
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
2.3.1.26 0.00007
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
2.3.1.26 0.00011
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
2.3.1.26 0.00032
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
2.3.1.26 0.00032
-
 isozyme ACAT2, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
2.3.1.26 0.00033
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2-fluorophenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.00079
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-cyanobenzoate
2.3.1.26 0.00178
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-chlorobenzoate
2.3.1.26 0.0022
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-cyanobenzoate
2.3.1.26 0.0027
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-chlorobenzoate
2.3.1.26 0.0027
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-fluorobenzoate
2.3.1.26 0.0028
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.003
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-fluorobenzoate
2.3.1.26 0.0034
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 2-methoxybenzoate
2.3.1.26 0.00373
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0043
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-bromobenzoate
2.3.1.26 0.0043
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 3-methoxybenzoate
2.3.1.26 0.0055
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-formylbenzoate
2.3.1.26 0.00554
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.0058
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-chlorobenzoate
2.3.1.26 0.0062
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.0069
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-bromobenzoate
2.3.1.26 0.0069
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-methoxybenzoate
2.3.1.26 0.00811
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(4-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.00951
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(3-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.01
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,4-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0139
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-2-phenyl-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-nitrobenzoate
2.3.1.26 0.0139
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-fluorobenzoate
2.3.1.26 0.0691
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(naphthalen-2-yl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.071
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-2-(2-methoxyphenyl)-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0712
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-2-(2,6-dimethylphenyl)-12-hydroxy-4a,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate
2.3.1.26 0.0728
-
 isozyme ACAT1, pH and temperature not specified in the publication Homo sapiens (2R,4bR,6S,6aS,12R,12aS,12bS,14aS)-12-hydroxy-4a,6a,12b-trimethyl-2-(2-methylphenyl)-11-oxo-9-(pyridin-3-yl)-4,4a,4b,5,6,6a,12,12a,12b,13,14,14a-dodecahydro-2H,11H-pyrano[3'',4'':5',6']pyrano[3',2':5,6]naphtho[2,1-d][1,3]dioxin-6-yl 4-cyanobenzoate