EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.7 | expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.7 | 0.078 | - |
acetyl-CoA | peroxisomal enzyme, at pH 7.4 and 37°C | Homo sapiens | |
2.3.1.7 | 0.24 | - |
acetyl-CoA | mitochondrial enzyme, at pH 7.4 and 37°C | Homo sapiens | |
2.3.1.7 | 0.499 | - |
butyryl-CoA | mitochondrial enzyme, at pH 7.4 and 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.7 | mitochondrion | - |
Homo sapiens | 5739 | - |
2.3.1.7 | peroxisome | - |
Homo sapiens | 5777 | - |
2.3.1.21 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.21 | additional information | Homo sapiens | the enzyme is inactive with short-chain acyl-CoAs and intermediates of the branched-chain amino acid oxidation pathway | ? | - |
? | |
2.3.1.21 | palmitoyl-CoA + L-carnitine | Homo sapiens | - |
CoA + L-palmitoylcarnitine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.7 | Homo sapiens | - |
- |
- |
2.3.1.21 | Homo sapiens | P23786 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.7 | HisLink protein purification resin column chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.7 | acetyl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-acetylcarnitine | - |
? | |
2.3.1.7 | butyryl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-butyrylcarnitine | - |
? | |
2.3.1.7 | additional information | the enzyme shows some activity with acyl-CoAs of longer chain length including C12- and C14-CoA, but not with C16-CoA. Trans-2-enoyl-CoA intermediates such as trans-2-ene-C4-CoA (crotonyl-CoA, trans-2-C4:1-CoA), trans-2-ene-3-methyl-C4-CoA (3-methylcrotonyl-CoA), and trans-2-ene-2-methyl-C4-CoA are poor substrates for the enzyme and no activity is found with dicarboxylic acyl-CoA esters | Homo sapiens | ? | - |
? | |
2.3.1.7 | octanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-octanoylcarnitine | - |
? | |
2.3.1.7 | palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-palmitoylcarnitine | - |
? | |
2.3.1.7 | propionyl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-propionylcarnitine | - |
? | |
2.3.1.21 | 4,8-dimethylnonanoyl-CoA + L-carnitine | - |
Homo sapiens | ? | - |
? | |
2.3.1.21 | additional information | the enzyme is inactive with short-chain acyl-CoAs and intermediates of the branched-chain amino acid oxidation pathway | Homo sapiens | ? | - |
? | |
2.3.1.21 | additional information | no activity with 2,6-dimethylheptanoyl-CoA | Homo sapiens | ? | - |
? | |
2.3.1.21 | palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.7 | carnitine acetyltransferase | - |
Homo sapiens |
2.3.1.7 | CRAT | - |
Homo sapiens |
2.3.1.21 | carnitine palmitoyltransferase 2 | - |
Homo sapiens |
2.3.1.21 | CPT2 | - |
Homo sapiens |