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Literature summary extracted from

  • Eto, M.; Shindou, H.; Shimizu, T.
    A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids (2014), Biochem. Biophys. Res. Commun., 443, 718-724.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.51 expressed in CHO-K1 cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.51 endoplasmic reticulum
-
 Mus musculus 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.51 37000
-
 x * 37000, SDS-PAGE Mus musculus
2.3.1.51 43800
-
 x * 43800, calculated from amino acid sequence Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate Mus musculus the enzyme has high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Mus musculus Q8K4X7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.51 adipose tissue
-
 Mus musculus
-
2.3.1.51 brain highest expression Mus musculus
-
2.3.1.51 colon
-
 Mus musculus
-
2.3.1.51 intestine
-
 Mus musculus
-
2.3.1.51 lung
-
 Mus musculus
-
2.3.1.51 Neuro-2a cell
-
 Mus musculus
-
2.3.1.51 stomach
-
 Mus musculus
-
2.3.1.51 testis
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-oleoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-palmitoyl-sn-glycerol 3-phosphate highest activity Mus musculus CoA + palmitoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-CoA + 1-stearoyl-sn-glycerol 3-phosphate
-
 Mus musculus CoA + 1-stearoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate the enzyme has high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA Mus musculus CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.51 ? x * 37000, SDS-PAGE Mus musculus
2.3.1.51 ? x * 43800, calculated from amino acid sequence Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.3.1.51 AGPAT4 formerly Mus musculus
2.3.1.51 LPAAT4
-
 Mus musculus
2.3.1.51 LPAATdelta formerly Mus musculus
2.3.1.51 lysophosphatidic acid acyltransferase
-
 Mus musculus