EC Number | Cloned (Comment) | Organism |
---|---|---|
2.1.1.224 | gene cfr, The Cfr-like protein in Peptoclostridium difficile is hosted by a transposon, and the same gene is found in other strains, sequence comparisons, overview. Recombinant expression in Escherichia coli strain AS19 which then shows elevated MIC values for five classes of antibiotics, and recombinant expression in rlmN-deficient Escherichia coli strain JW2505-1 | Clostridioides difficile |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.224 | 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin | Clostridioides difficile | - |
S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.224 | Clostridioides difficile | V5ZEZ1 | formerly Clostridium difficile, gene cfr | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.224 | 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin | - |
Clostridioides difficile | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.224 | Cfr | - |
Clostridioides difficile |
2.1.1.224 | Cfr-like protein | - |
Clostridioides difficile |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.224 | Ferredoxin | - |
Clostridioides difficile | |
2.1.1.224 | S-adenosyl-L-methionine | - |
Clostridioides difficile |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.1.1.224 | physiological function | the Cfr RNA methyltransferase causes multiple resistances to peptidyl transferase inhibitors by methylation of A2503 23S rRNA | Clostridioides difficile |