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Literature summary extracted from

  • Chen, J.; Liang, Z.; Wang, W.; Yi, C.; Zhang, S.; Zhang, Q.
    Revealing origin of decrease in potency of darunavir and amprenavir against HIV-2 relative to HIV-1 protease by molecular dynamics simulations (2014), Sci. Rep., 4, 6872.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.23.47 molecular dynamics simulations in complerx with inhibitors amprenvir and darunavir HIV-2 subtype A

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.47 amprenavir inhibitor binds less strongly to HIV-2 protease than to HIV-2 protease due to a reduction of the van der Waals interactions. Inhibitor binding tends to make the flaps of PR2 close and the one of PR1 open HIV-2 subtype A
3.4.23.47 darunavir inhibitor binds less strongly to HIV-2 protease than to HIV-2 protease due to a reduction of the van der Waals interactions. Inhibitor binding tends to make the flaps of PR2 close and the one of PR1 open HIV-2 subtype A

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.47 HIV-2 subtype A P04584
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