Literature summary extracted from
Chen, J.; Liang, Z.; Wang, W.; Yi, C.; Zhang, S.; Zhang, Q.
Revealing origin of decrease in potency of darunavir and amprenavir against HIV-2 relative to HIV-1 protease by molecular dynamics simulations (2014), Sci. Rep., 4, 6872.
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
3.4.23.47 |
molecular dynamics simulations in complerx with inhibitors amprenvir and darunavir |
HIV-2 subtype A |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.4.23.47 |
amprenavir |
inhibitor binds less strongly to HIV-2 protease than to HIV-2 protease due to a reduction of the van der Waals interactions. Inhibitor binding tends to make the flaps of PR2 close and the one of PR1 open |
HIV-2 subtype A |
|
3.4.23.47 |
darunavir |
inhibitor binds less strongly to HIV-2 protease than to HIV-2 protease due to a reduction of the van der Waals interactions. Inhibitor binding tends to make the flaps of PR2 close and the one of PR1 open |
HIV-2 subtype A |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.23.47 |
HIV-2 subtype A |
P04584 |
- |
- |