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Literature summary extracted from

  • Gu, Y.; Lee, W.; Shen, J.
    Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells (2014), Sci. Rep., 4, 6268.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.85 Cricetulus griseus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.85 CHO cell
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 Cricetulus griseus
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Expression

EC Number Organism Comment Expression
3.4.24.85 Cricetulus griseus oxidative stress significantly up-regulates site-2 protease expression in CHO cells up

General Information

EC Number General Information Comment Organism
3.4.24.85 physiological function cells defective in the site-2 protease gene have remarkably higher level of superoxide and elevated rates of cell death than wild-type CHO cells. Lack of the site-2 proease gene leads to cells more vulnerable to oxidative stress. Compared with wild-type CHO cells, mutant cells have higher nicotinamide adenine dinucleotide phosphate oxidase activity and lower paraoxonase-2 expression Cricetulus griseus