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Literature summary extracted from

  • Magen, S.; Magnani, R.; Haziza, S.; Hershkovitz, E.; Houtz, R.; Cambi, F.; Parvari, R.
    Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence (2012), PLoS ONE, 7, e52425.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.60 expressed in COS-7 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.60 cytoplasm
-
 Mus musculus 5737
-
2.1.1.60 cytoplasm
-
 Homo sapiens 5737
-
2.1.1.60 Golgi apparatus
-
 Mus musculus 5794
-
2.1.1.60 Golgi apparatus short isoform Homo sapiens 5794
-
2.1.1.60 nucleus
-
 Mus musculus 5634
-
2.1.1.60 nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.60 36000
-
 x * 36000, SDS-PAGE Mus musculus
2.1.1.60 36000
-
 x * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine Mus musculus
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine Homo sapiens
-
 S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.60 Homo sapiens Q7Z624
-
-
2.1.1.60 Mus musculus Q3U2J5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.60 brain
-
 Mus musculus
-
2.1.1.60 HEK-293 cell
-
 Homo sapiens
-
2.1.1.60 HeLa cell
-
 Homo sapiens
-
2.1.1.60 muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine
-
 Mus musculus S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?
2.1.1.60 S-adenosyl-L-methionine + calmodulin L-lysine
-
 Homo sapiens S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.60 ? x * 36000, SDS-PAGE Mus musculus
2.1.1.60 ? x * 36000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.1.1.60 calmodulin methyltransferase
-
 Mus musculus
2.1.1.60 calmodulin methyltransferase
-
 Homo sapiens
2.1.1.60 CaM KMT
-
 Mus musculus
2.1.1.60 CaM KMT previously C2orf34 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.60 malfunction the absence of enzyme causes accumulation of hypomethylated calmodulin in 2p21 deletion syndrome patients Homo sapiens
2.1.1.60 metabolism the enzyme is the major methyltransferase of calmodulin in human cells and a Hsp90 client protein Homo sapiens