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Literature summary extracted from

  • Medina, J.M.; Rodrigues, J.C.; De Souza, W.; Atella, G.C.; Barrabin, H.
    Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes (2012), Parasitology, 139, 1253-1265.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.143 tomatidine
-
 Leishmania amazonensis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.143 S-adenosyl-L-methionine + 24-methylene-cholesta-5,7-dien-3beta-ol Leishmania amazonensis
-
 S-adenosyl-L-homocysteine + cholesta-8,24-dien-3beta-ol
-
 ?
2.1.1.143 S-adenosyl-L-methionine + 24-methylene-cholesta-5,7-dien-3beta-ol Leishmania amazonensis MHOM/BR/75/Josefa
-
 S-adenosyl-L-homocysteine + cholesta-8,24-dien-3beta-ol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.143 Leishmania amazonensis
-
-
-
2.1.1.143 Leishmania amazonensis MHOM/BR/75/Josefa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.143 promastigote
-
 Leishmania amazonensis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.143 S-adenosyl-L-methionine + 24-methylene-cholesta-5,7-dien-3beta-ol
-
 Leishmania amazonensis S-adenosyl-L-homocysteine + cholesta-8,24-dien-3beta-ol
-
 ?
2.1.1.143 S-adenosyl-L-methionine + 24-methylene-cholesta-5,7-dien-3beta-ol
-
 Leishmania amazonensis MHOM/BR/75/Josefa S-adenosyl-L-homocysteine + cholesta-8,24-dien-3beta-ol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.143 24-sterol methyltransferase
-
 Leishmania amazonensis