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Literature summary extracted from

  • Du, Y.; Zhang, H.; Hong, L.; Wang, J.; Zheng, X.; Zhang, Z.
    Acetolactate synthases MoIlv2 and MoIlv6 are required for infection-related morphogenesis in Magnaporthe oryzae (2013), Mol. Plant Pathol., 14, 870-884.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.2.1.6 genes MGG_01104 and MGG_06868, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, recombinant expression of GFP-tagged subunits in the deletion mutant strains, subcellular localization of both MoIlv2 and MoIlv6 to the mitochondria Pyricularia oryzae

Protein Variants

EC Number Protein Variants Comment Organism
2.2.1.6 additional information generation of the deletion mutants DELTAMoilv2 and DELTAMoilv6. Phenotypic analysis shows that both mutants are auxotrophic for leucine, isoleucine and valine, and are defective in conidial morphogenesis, appressorial penetration and pathogenicity Pyricularia oryzae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.2.1.6 mitochondrion
-
 Pyricularia oryzae 5739
-
2.2.1.6 mitochondrion MoIlv2 and MoIlv6 are both localized to the mitochondria and the signal peptide of MoIlv6 is critical for its localization Pyricularia oryzae 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 2 pyruvate Pyricularia oryzae
-
 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate Pyricularia oryzae Guy11
-
 2-acetolactate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Pyricularia oryzae
-
-
-
2.2.1.6 Pyricularia oryzae G4NC97 and G4MMK2 small subunit Moilv6 and large subunit Moilv2; genes ilv2 and ilv6 encoding the catalytic and the regulatory subunit, respectively
-
2.2.1.6 Pyricularia oryzae Guy11
-
-
-
2.2.1.6 Pyricularia oryzae Guy11 G4NC97 and G4MMK2 small subunit Moilv6 and large subunit Moilv2; genes ilv2 and ilv6 encoding the catalytic and the regulatory subunit, respectively
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.2.1.6 mycelium
-
 Pyricularia oryzae
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 2 pyruvate
-
 Pyricularia oryzae 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate
-
 Pyricularia oryzae Guy11 2-acetolactate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.2.1.6 More the enzyme has a catalytic subunit and a regulatory subunit, encoded by two different genes Pyricularia oryzae

Synonyms

EC Number Synonyms Comment Organism
2.2.1.6 ALS
-
 Pyricularia oryzae
2.2.1.6 Ilv2 isoform Pyricularia oryzae
2.2.1.6 Ilv6 isoform Pyricularia oryzae
2.2.1.6 Moilv2
-
 Pyricularia oryzae
2.2.1.6 Moilv6
-
 Pyricularia oryzae

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.6 thiamine diphosphate
-
 Pyricularia oryzae

General Information

EC Number General Information Comment Organism
2.2.1.6 malfunction the deletion mutants DELTAMoilv2 and DELTAMoilv6 are both auxotrophic for leucine, isoleucine and valine, and are defective in conidial morphogenesis, appressorial penetration and pathogenicity, phenotypes, overview Pyricularia oryzae
2.2.1.6 metabolism acetolactate synthase catalyses the first common step in leucine, isoleucine and valine biosynthesis Pyricularia oryzae
2.2.1.6 metabolism isoform Ilv2 plays a crucial role in isoleucine and valine biosynthesis, isoform Ilv6 contributes to isoleucine and leucine biosynthesis Pyricularia oryzae
2.2.1.6 additional information the domains are crucial to the function of MoIlv2 and MoIlv6 during pathogenicity on rice and barley leaves, functional analysis of enzyme domains, overview Pyricularia oryzae
2.2.1.6 physiological function MoIlv2 plays a crucial role in isoleucine and valine biosynthesis, whereas MoIlv6 contributes to isoleucine and leucine biosynthesis, both genes are required for fungal pathogenicity. MoIlv2 and MoIlv6 play a critical role in maintaining the balance of intracellular amino acid levels. And MoIlv2 and MoIlv6 are involved in aerial hyphal growth, pigmentation, conidial morphogenesis and pathogenicity on rice and barley Pyricularia oryzae
2.2.1.6 physiological function the enzyme plays a critical role in maintaining the balance of intracellular amino acid level, is involved in aerial hyphal growth, pigmentation, conidial morphogenesis, and is required for fungal pathogenicity Pyricularia oryzae