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Literature summary extracted from

  • Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
    A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently (2014), J. Cell Sci., 127, 3488-3504.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.23 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine Homo sapiens
-
 [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.23 Homo sapiens
-
-
-
2.3.2.27 Homo sapiens O60260
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.23 HEK-293 cell
-
 Homo sapiens
-
2.3.2.23 HeLa cell
-
 Homo sapiens
-
2.3.2.27 HEK-293 cell
-
 Homo sapiens
-
2.3.2.27 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.23 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.23 E2 ubiquitin conjugating enzyme
-
 Homo sapiens
2.3.2.23 UBE2D
-
 Homo sapiens
2.3.2.23 UBE2L3
-
 Homo sapiens
2.3.2.23 UBE2N
-
 Homo sapiens
2.3.2.23 UBE2R1
-
 Homo sapiens
2.3.2.27 Parkin
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.2.23 malfunction knockdown of E2 enzymes delays ubiquitylation and degradation of mitochondrial substrates like p62 and the adaptor protein p62/SQSTM1. Depletion of UBE2R1 enhances the translocation of Parkin to, and clustering of, mitochondria Homo sapiens
2.3.2.23 physiological function the cognate E2 coenzymes of E3 enzyme Parkin regulate the activation, translocation and enzymatic functions of Parkin during mitochondrial quality control. UBE2D family members and UBE2L3 redundantly charge the RING-HECT hybrid ligase Parkin with ubiquitin, resulting in its initial activation and translocation to mitochondria. UBE2N primarily mediates the proper clustering of mitochondria, a prerequisite for degradation. Depletion of UBE2R1 results in enhanced Parkin translocation and clustering upon mitochondrial uncoupling Homo sapiens
2.3.2.23 physiological function E2 enzymes regulate activation and mitochondrial translocation of Parkin. UBE2L3 is able to charge Parkin with ubiquitin and are essential for its initial activation Homo sapiens
2.3.2.27 metabolism the cognate E2 co-enzymes of E3 enzyme Parkin regulate the activation, translocation and enzymatic functions of Parkin during mitochondrial quality control. UBE2D family members and UBE2L3 redundantly charge the RING-HECT hybrid ligase Parkin with ubiquitin, resulting in its initial activation and translocation to mitochondria. UBE2N primarily mediates the proper clustering of mitochondria, a prerequisite for degradation. Depletion of UBE2R1 results in enhanced Parkin translocation and clustering upon mitochondrial uncoupling Homo sapiens