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Literature summary extracted from

  • Morris, L.L.; Hartman, I.Z.; Jun, D.J.; Seemann, J.; DeBose-Boyd, R.A.
    Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (2014), J. Biol. Chem., 289, 19053-19066.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.5 cytosol
-
 Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.5 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide Mus musculus
-
 ADP + phosphate + unfolded polypeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.5 Mus musculus O88685 Rpt5 or 26S protease regulatory subunit 6A
-
5.6.1.5 Mus musculus P54775 Rpt3 or 26S protease regulatory subunit 6B
-
5.6.1.5 Mus musculus P62192 Rpt2 or 26S protease regulatory subunit 4
-
5.6.1.5 Mus musculus P62196 Rpt6 or 26S protease regulatory subunit 8
-
5.6.1.5 Mus musculus P62334 Rpt4 or 26S protease regulatory subunit 10B
-
5.6.1.5 Mus musculus Q8BVQ9 Rpt1 or 26S protease regulatory subunit 7
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.5 ATP + H2O + polypeptide
-
 Mus musculus ADP + phosphate + unfolded polypeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.5 26S protease regulatory subunit 10B
-
 Mus musculus
5.6.1.5 26S protease regulatory subunit 4
-
 Mus musculus
5.6.1.5 26S protease regulatory subunit 6A
-
 Mus musculus
5.6.1.5 26S protease regulatory subunit 6B
-
 Mus musculus
5.6.1.5 26S protease regulatory subunit 7
-
 Mus musculus
5.6.1.5 26S protease regulatory subunit 8
-
 Mus musculus
5.6.1.5 Rpt1
-
 Mus musculus
5.6.1.5 Rpt2
-
 Mus musculus
5.6.1.5 Rpt3
-
 Mus musculus
5.6.1.5 Rpt4
-
 Mus musculus
5.6.1.5 Rpt5
-
 Mus musculus
5.6.1.5 Rpt6
-
 Mus musculus

General Information

EC Number General Information Comment Organism
5.6.1.5 malfunction in cells deficient for AAA-ATPases of the proteasome 19S regulatory particle, the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase continued to become membrane-extracted, but not cytosolically dislocated Mus musculus
5.6.1.5 physiological function ATPase of the 19S regulatory particle, RP, subcomplex of the 26S proteasome Mus musculus