Literature summary extracted from
Ding, Y.; Zhang, Y.; Xu, C.; Tao, Q.H.; Chen, Y.G.
HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradation (2013), J. Biol. Chem., 288, 8289-8298.
Localization
EC Number |
Localization |
Comment |
Organism |
GeneOntology No. |
Textmining |
---|
2.3.2.26 |
cytoplasm |
- |
Homo sapiens |
5737 |
- |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.2.26 |
Homo sapiens |
Q96PU5 |
isoform 2 |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.3.2.26 |
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Dvl2]-L-lysine |
Dvl2 i.e. dishevelled, a central mediator for both Wnt/beta-catenin and Wnt/planar cell polarity pathways |
Homo sapiens |
[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[Dvl2]-L-lysine |
isoform NEDD4L mediates polyubiquitination of Dvl2 at Lys6, Lys27, and Lys29 |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.3.2.26 |
Nedd4L |
- |
Homo sapiens |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.3.2.26 |
physiological function |
isoform NEDD4L induces Dvl2 polyubiquitination and targets Dvl2 for proteasomal degradation, thereby regulating the cellular beta-catenin level and Rac1, RhoA, and JNK activities |
Homo sapiens |