Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Woskowicz, A.M.; Weaver, S.A.; Shitomi, Y.; Ito, N.; Itoh, Y.
    MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion (2013), J. Biol. Chem., 288, 35126-35137.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.80 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 tissue inhibitor of metalloproteinase 2
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.80 55000
-
 x * 55000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.80 pro-MMP-2 + H2O Homo sapiens
-
 MMP-2 + propeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Homo sapiens P50281
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.80
-
 Homo sapiens

Renatured (Commentary)

EC Number Renatured (Comment) Organism
3.4.24.80
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 A-431 cell
-
 Homo sapiens
-
3.4.24.80 HeLa cell
-
 Homo sapiens
-
3.4.24.80 HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 Collagen + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 F-gelatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.80 pro-MMP-2 + H2O
-
 Homo sapiens MMP-2 + propeptide
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.80 ? x * 55000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 membrane type 1 matrix metalloproteinase
-
 Homo sapiens
3.4.24.80 MT1-MMP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.80 physiological function the enzyme promotes cancer cell invasion. The MT-LOOP-dependent enzyme localization to the cell adhesion complex promotes cellular invasion (the MT-LOOP is a region in the catalytic domain of MT1-MMP (163PYAYIREG170)) Homo sapiens