Literature summary extracted from
Shaaly, A.; Kalamorz, F.; Gebhard, S.; Cook, G.M.
Undecaprenyl pyrophosphate phosphatase confers low-level resistance to bacitracin in Enterococcus faecalis (2013), J. Antimicrob. Chemother., 68, 1583-1593.
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.6.1.27 |
Enterococcus faecalis |
Q5WNX2 |
- |
- |
Expression
EC Number |
Organism |
Comment |
Expression |
---|
3.6.1.27 |
Enterococcus faecalis |
expression of is constitutive and not affected by bacitracin or cell wall-active antimicrobials |
additional information |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.6.1.27 |
physiological function |
mutants lacking enzymic activity show no significant changes in growth rate, colony morphology and biofilm formation. The mutants exhibit increased susceptibility to bacitracin. When the enzyme is expressed in a wild-type background, the minimum inhibitory concentration of bacitracin increases to 256 mg/L. The minimum inhibitory concentrations of cefoxitin, teicoplanin, vancomycin, gentamicin, enrofloxacin and D-cycloserine are unaltered in the mutant relative to the wild-type, as are susceptibilities to other stress agents such as glycine, lysozyme, NaCl, SDS, low and high pH, oxidative stress and ethanol |
Enterococcus faecalis |