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Literature summary extracted from
- Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease (2013), J. Alzheimers Dis., 33, S101.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.24.71 | C338A | the mutation in isoform ECE-1b creates a new E2F-2 transcription factor binding site and enhances expression of this intracellular isoform | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.71 | endosome | - |
Homo sapiens | 5768 | - |
| 3.4.24.71 | multivesicular body | - |
Homo sapiens | 5771 | - |
| 3.4.24.71 | plasma membrane | - |
Homo sapiens | 5886 | - |
| 3.4.24.71 | secretory vesicle | - |
Homo sapiens | 99503 | - |
| 3.4.24.71 | trans-Golgi network | - |
Homo sapiens | 5802 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.71 | amyloid beta peptide + H2O | Homo sapiens | - |
? | - |
? |  |
| 3.4.24.71 | angiotensin I + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.71 | big endothelin + H2O | Homo sapiens | - |
endothelin + ? | - |
? | |
| 3.4.24.71 | bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.71 | neurotensin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.71 | somatostatin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.71 | Substance P + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | Homo sapiens | P42892 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.71 | amyloid beta peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.71 | angiotensin I + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.71 | big endothelin + H2O | - |
Homo sapiens | endothelin + ? | - |
? | |
| 3.4.24.71 | bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.71 | neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.71 | somatostatin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.71 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.71 | ECE-1 | - |
Homo sapiens |
| 3.4.24.71 | ECE-1b | isoform | Homo sapiens |
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