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Literature summary extracted from

  • Zuljan, F.A.; Repizo, G.D.; Alarcon, S.H.; Magni, C.
    alpha-Acetolactate synthase of Lactococcus lactis contributes to pH homeostasis in acid stress conditions (2014), Int. J. Food Microbiol., 188, 99-107.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.2.1.6 gene als, amino acid sequence determination and analysis, sequence comparisons Lactococcus lactis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 2 pyruvate Lactococcus lactis
-
 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate Lactococcus lactis IL1403
-
 2-acetolactate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Lactococcus lactis
-
-
-
2.2.1.6 Lactococcus lactis Q7DAV2 gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als
-
2.2.1.6 Lactococcus lactis IL1403
-
-
-
2.2.1.6 Lactococcus lactis IL1403 Q7DAV2 gene als; subsp. lactis biovar. diacetylactis, derived from strain IL594, which is isolated from a starter culture for cheese, gene als
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.2.1.6 additional information growth conditions and pH-dependencies of wild-type and mutant als strains, overview Lactococcus lactis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 2 pyruvate
-
 Lactococcus lactis 2-acetolactate + CO2
-
 ?
2.2.1.6 2 pyruvate
-
 Lactococcus lactis IL1403 2-acetolactate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.2.1.6 alpha-acetolactate synthase
-
 Lactococcus lactis

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.6 thiamine diphosphate
-
 Lactococcus lactis

General Information

EC Number General Information Comment Organism
2.2.1.6 malfunction the als defective strain, which is incapable of producing C4 compounds, appears sensitive to pyruvate under acidic conditions rendering it unable to grow. Accordingly, the als-mutant strain shows a simultaneous inability to alkalinize internal and external media Lactococcus lactis
2.2.1.6 metabolism strain IL1403 is able to cometabolize pyruvate and glucose at low pH, producing lactate, acetate as well as diacetyl/acetoin compounds. The enzyme is involved in the pyruvate metabolism in Lactococcus lactis, overview Lactococcus lactis
2.2.1.6 physiological function the enzyme contributes to pH homeostasis in acid stress conditions Lactococcus lactis