Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lewis, L.A.; Choudhury, B.; Balthazar, J.T.; Martin, L.E.; Ram, S.; Rice, P.A.; Stephens, D.S.; Carlson, R.; Shafer, W.M.
    Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum (2009), Infect. Immun., 77, 1112-1120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.43 gene lptA Neisseria gonorrhoeae

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.43 additional information piliated colony variants of strain FA19 are transformed with plasmid or chromosomal DNA preparations bearing insertionally inactivated lpt3, lpt6, or lptA genes prepared previously from Neisseria meningitidis strain NMB Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae FA19 addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Neisseria gonorrhoeae FA19 addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Neisseria gonorrhoeae
-
 gene lptA
-
2.7.8.43 Neisseria gonorrhoeae FA19
-
 gene lptA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A Neisseria gonorrhoeae diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 1-position of lipid A Neisseria gonorrhoeae FA19 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A Neisseria gonorrhoeae diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A addition of phosphoethanolamine to the phosphate group at the 4'-position of lipid A Neisseria gonorrhoeae FA19 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 additional information phosphoethanolamine substitution at both the 1 and 4' positions of lipid A, component of lipooligosaccharide. Lipooligosaccharide structure analysis by MALDI-TOF mass spectrometry, overview Neisseria gonorrhoeae ?
-
 ?
2.7.8.43 additional information phosphoethanolamine substitution at both the 1 and 4' positions of lipid A, component of lipooligosaccharide. Lipooligosaccharide structure analysis by MALDI-TOF mass spectrometry, overview Neisseria gonorrhoeae FA19 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 LptA
-
 Neisseria gonorrhoeae

General Information

EC Number General Information Comment Organism
2.7.8.43 malfunction loss of phosphoethanolamine substitution from the lipid A component of lipooligosaccharide, due to insertional inactivation of lptA, results in increased gonococcal susceptibility to polymyxin B. Loss of phosphoethanolamine attached to lipid A at 4' position renders strain FA19 susceptible to complement killing. Serum killing of the lptA mutant occurs through the classical complement pathway. Both serum and polymyxin B resistance as well as phosphoethanolamine decoration of lipid A are restored in the lptA-null mutant by complementation with wild-type lptA Neisseria gonorrhoeae