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Literature summary extracted from

  • Huang, J.; Barr, E.; Rudnick, D.A.
    Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration (2013), Hepatology, 57, 1742-1751.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 suberoylanilide hydroxyamic acid a specific inhibitor of zinc-dependent histone deacetylase activity. The compound directly induces p19INK4d expression in regenerating liver by increasing p19INK4d promoter-associated histone acetylation, molecular mechanisms by which the inhibitor delays liver regeneration exerting promoter-specific effects on histone acetylation during liver regeneration, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.98 cytoplasm subcellular localization of the class II HDACs 4, 5, and 7 is regulated by phosphorylation-dependent shuttling between the cytoplasmic and nuclear compartments Mus musculus 5737
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3.5.1.98 nucleus isozymes HDACs 1 and 2 are exclusively localized in the nucleus Mus musculus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.98 Zn2+ zinc-dependent enzyme Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 liver
-
 Mus musculus
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Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 zinc-dependent histone deacetylase
-
 Mus musculus
3.5.1.98 Zn-HDAC
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.5.1.98 Mus musculus the hepatic enzyme activity is significantly increased in nuclear and cytoplasmic fractions following partial hepatectomy. Isoform-specific effects of partial hepatectomy on isozyme HDAC mRNA and protein expression, with increased isozyme expression of the class I HDACs, 1 and 8, and class II HDAC4 in regenerating liver. Hepatic expression of (class II) HDAC5 is unchanged after partial hepatectomy, HDAC5 exhibits transient nuclear accumulation in regenerating liver up

General Information

EC Number General Information Comment Organism
3.5.1.98 additional information isoform-specific regulation of zinc-dependent histone deacetylase expression, subcellular localization, and activity in regenerating liver. The signals that regulate the PH-induced metabolic response to hepatic insufficiency are not downstream, but might be upstream, of the target of suberoylanilide hydroxyamic acid's anti-regenerative activity Mus musculus
3.5.1.98 physiological function the enzyme activity promotes liver regeneration by regulating hepatocellular cell cycle progression at a step downstream of cyclin D1 induction Mus musculus