Literature summary extracted from

Kleinegris, M.C.; Koek, G.H.; Mast, K.; Mestrom, E.H.; Wolfs, J.L.; Bevers, E.M.
Ribavirin-induced externalization of phosphatidylserine in erythrocytes is predominantly caused by inhibition of aminophospholipid translocase activity (2012), Eur. J. Pharmacol., 693, 1-6.

Application

EC Number	Application	Comment	Organism
7.6.2.1	medicine	spontaneous loss of lipid asymmetry, not corrected by aminophospholipid translocase activity, is the mechanism for ribavirin-induced phosphatidylserine exposure that may contribute to ribavirin-induced anemia	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.6.2.1	ribavirin	prolonged treatment of erythrocytes with ribavirin results in surface exposure of phosphatidylserine, mainly caused by inactivation of the aminophospholipid translocase. Inactivation is due to severe ATP depletion	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.6.2.1	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
7.6.2.1	erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.6.2.1	fluorescent labeled phosphatidylserine/outer leaflet + ATP + H2O	enzyme specifically transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane	Homo sapiens	fluorescent labeled phosphatidylserine/inner leaflet + ADP + phosphate	-	?

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Release 2023.1 (January 2023)