EC Number | Application | Comment | Organism |
---|---|---|---|
3.5.1.5 | drug development | urease is considered a first line target for drug development and vaccination against Helicobacter pylori infection | Helicobacter pylori |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.5 | Hpn protein | synthesis and purifcation of the 7 kDa protein, the synthetic nickel-binding histidine-rich protein designated Hpn is capable of abrogating urease activity of live Heicobacter pylori in liquid cultures due to inhibition of nickel uptake into cells | Helicobacter pylori |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.1.5 | Ni2+ | the catalytic activity of urease is mediated by nickel ions | Helicobacter pylori |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.5 | urea + H2O | Helicobacter pylori | - |
CO2 + 2 NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.1.5 | Helicobacter pylori | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.1.5 | urea + H2O | - |
Helicobacter pylori | CO2 + 2 NH3 | - |
? |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.5.1.5 | physiological function | neutralization of acid by ammonia is essential for gastric Helicobacter pylori colonization | Helicobacter pylori |