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Literature summary extracted from

  • Lougiakis, N.; Marakos, P.; Pouli, N.; Fragopoulou, E.; Tenta, R.
    Synthesis of new nebularine analogues and their inhibitory activity against adenosine deaminase (2015), Chem. Pharm. Bull., 63, 134-142.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 2,2,2-trifluoro-N-[7-chloro-5-methyl-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-yl]-acetamide 20% inhibition at 0.4 mM Bos taurus
3.5.4.4 2,2,2-trifluoro-N-[7-chloro-5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-yl]acetamide 23% inhibition at 0.4 mM Bos taurus
3.5.4.4 5-(beta-D-ribofuranosyl)-1H,5H-imidazo[4,5-b]pyrazolo[3,4-e]pyridine 25% inhibition at 0.4 mM Bos taurus
3.5.4.4 5-methyl-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 19% inhibition at 0.4 mM Bos taurus
3.5.4.4 5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 6% inhibition at 0.4 mM Bos taurus
3.5.4.4 5-methyl-6-nitro-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridine 31% inhibition at 0.4 mM Bos taurus
3.5.4.4 5-methyl-6-nitro-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridine 25% inhibition at 0.4 mM Bos taurus
3.5.4.4 7-(beta-D-ribofuranosyl)-1H,7H-imidazo[4,5-b]pyrazolo[3,4-e]pyridine 7% inhibition at 0.4 mM Bos taurus
3.5.4.4 7-chloro-5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 15% inhibition at 0.4 mM Bos taurus
3.5.4.4 nebularine i.e. 9-beta-D-ribofuranosylpurine, competitive inhibitor Bos taurus
3.5.4.4 pentostatin
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.4 adenosine + H2O Bos taurus
-
 inosine + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Bos taurus P56658
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.4.4 ADA
-
 Bos taurus