Literature summary extracted from

Bizouarn, T.; Grimley, R.L.; Cotton, N.P.; Stilwell, S.N.; Hutton, M.; Jackson, J.B.
The involvement of NADP(H) binding and release in energy transduction by proton-translocating nicotinamide nucleotide transhydrogenase from Escherichia coli (1995), Biochim. Biophys. Acta, 1229, 49-58.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.1.1.1	NADH	high concentrations of NADH lead to substrate inhibition	Escherichia coli
7.1.1.1	oxidized 3-acetylpyridin-adenine dinucleotide	high concentrations of oxidized 3-acetylpyridin-adenine dinucleotide lead to substrate inhibition	Escherichia coli

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.1.1.1	membrane	-	Escherichia coli	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
7.1.1.1	NADPH + NAD+ + H+[side 1]	Escherichia coli	-	NADP+ + NADH + H+[side 2]	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.1.1.1	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.1.1.1	NADPH + NAD+ + H+[side 1]	-	Escherichia coli	NADP+ + NADH + H+[side 2]	-	?
7.1.1.1	NADPH + oxidized 3-acetylpyridin-adenine dinucleotide + H+[side 1]	-	Escherichia coli	NADP+ + reduced 3-acetylpyridin-adenine dinucleotide + H+[side 2]	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
7.1.1.1	proton-translocating nicotinamide nucleotide transhydrogenase	-	Escherichia coli

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Release 2023.1 (January 2023)