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Literature summary extracted from

  • Golin, J.; Ambudkar, S.V.
    The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters (2015), Biochem. J., 467, 353-363.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
7.6.2.2 D1042N the mutant exhibits an rhodamine 6G efflux rate that is 10% as high as that of the wild type Saccharomyces cerevisiae
7.6.2.2 S1368A the mutant has wild type enzyme levels as well as wild type ATPase activity and transmembrane signaling Saccharomyces cerevisiae
7.6.2.2 S558Y the mutation leads to markedly increased hypersensitivity towards all transport substrates Saccharomyces cerevisiae
7.6.2.2 V656A the mutation leads to markedly increased hypersensitivity towards all transport substrates Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 beryllium fluoride
-
 Saccharomyces cerevisiae
7.6.2.2 clotrimazole
-
 Saccharomyces cerevisiae
7.6.2.2 vanadate
-
 Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
 Saccharomyces cerevisiae 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic/in Saccharomyces cerevisiae
-
 ADP + phosphate + xenobiotic/out
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + clotrimazole/in
-
 Saccharomyces cerevisiae ADP + phosphate + clotrimazole/out
-
 ?
7.6.2.2 ATP + H2O + rhodamine 6G/in
-
 Saccharomyces cerevisiae ADP + phosphate + rhodamine 6G/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in
-
 Saccharomyces cerevisiae ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 CTP + H2O + rhodamine 6G/in low CTPase activity Saccharomyces cerevisiae CDP + phosphate + rhodamine 6G/out
-
 ?
7.6.2.2 GTP + H2O + rhodamine 6G/in
-
 Saccharomyces cerevisiae GDP + phosphate + rhodamine 6G/out
-
 ?
7.6.2.2 UTP + H2O + rhodamine 6G/in low UTPase activity Saccharomyces cerevisiae UDP + phosphate + rhodamine 6G/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 PDR5
-
 Saccharomyces cerevisiae