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Literature summary extracted from

  • Weil, A.F.; Ghosh, D.; Zhou, Y.; Seiple, L.; McMahon, M.A.; Spivak, A.M.; Siliciano, R.F.; Stivers, J.T.
    Uracil DNA glycosylase initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration (2013), Proc. Natl. Acad. Sci. USA, 110, E448-E457.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.27 Ugi peptide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.2.27 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O Homo sapiens
-
 uracil + DNA with abasic site
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.27 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.27 HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O
-
 Homo sapiens uracil + DNA with abasic site
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.27 UNG2 isoform Homo sapiens
3.2.2.27 uracil DNA glycosylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.2.2.27 malfunction inhibition of endogenous isoform UNG2 does not affect reverse transcription, permits integration of uracilated viruses but does not rescue viral protein expression Homo sapiens
3.2.2.27 physiological function isoform UNG2 initiates degradation of HIV-1 cDNA containing misincorporated dUTP and prevents viral integration Homo sapiens