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Literature summary extracted from

  • Sanderson-Smith, M.L.; Zhang, Y.; Ly, D.; Donahue, D.; Hollands, A.; Nizet, V.; Ranson, M.; Ploplis, V.A.; Walker, M.J.; Castellino, F.J.
    A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection (2013), PLoS Pathog., 9, e1003469.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.73 additional information generation of strain AlbPLG1/uPA-/- enzyme-deficient mice Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.73 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens P00749
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.73 proteolytic modification activation of enzyme zymogen. Group A Streptococci are able to mediate a significant increase in the activation of zymogen pro-enzyme in human plasma. The zymogen pro-uPA can be activated by a variety of proteases, including plasmin Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase-type plasminogen activator
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.73 malfunction both C57/black 6J, and AlbPLG1 mice expressing the human plasminogen transgene, are significantly more susceptible to invasive Group A Streptococcus strain 5448 disease than enzyme-deficient uPA-/- mice. The observed decrease in virulence in uPA-/- mice correlates directly with a decrease in bacterial dissemination and reduced cell surface plasmin accumulation by Group A Streptococci Homo sapiens
3.4.21.73 physiological function the enzyme is primarily involved in cell-associated plasminogen activation. Urokinase-type plasminogen activator contributes to plasmin recruitment and subsequent invasive disease initiation by invasive Group A streptococci in vivo, it hhas a key role in cell surface plasmin acquisition and bacterial dissemination in invasive Group A streptococcus disease Homo sapiens