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Literature summary extracted from

  • Kitamura, K.; Wang, Z.; Chowdhury, S.; Simadu, M.; Koura, M.; Muramatsu, M.
    Uracil DNA glycosylase counteracts APOBEC3G-induced hypermutation of hepatitis B viral genomes: excision repair of covalently closed circular DNA (2013), PLoS Pathog., 9, e1003361.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.27 Ugi peptide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O Homo sapiens
-
 uracil + DNA with abasic site
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.27 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.27 uracil-mismatched DNA + H2O
-
 Homo sapiens uracil + DNA with abasic site
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.27 UNG
-
 Homo sapiens
3.2.2.27 uracil DNA glycosylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.2.2.27 malfunction enzyme inhibition enhances APOBEC3G-induced hypermutation of hepatitis B virus nucleocapsid-associated DNA Homo sapiens
3.2.2.27 physiological function uracil DNA glycosylase is a base excision repair enzyme that removes uracil residues from DNA following dUTP misincorporations or cytosine deaminations. The enzyme is also essential for class-switch recombination and somatic hypermutation Homo sapiens