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Literature summary extracted from

  • Daimon, T.; Kozaki, T.; Niwa, R.; Kobayashi, I.; Furuta, K.; Namiki, T.; Uchino, K.; Banno, Y.; Katsuma, S.; Tamura, T.; Mita, K.; Sezutsu, H.; Nakayama, M.; Itoyama, K.; Shimada, T.; Shinoda, T.
    Precocious metamorphosis in the juvenile hormone-deficient mutant of the silkworm, Bombyx mori (2012), PLoS Genet., 8, e1002486.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.128 expression in Sf2 or Sf9 cells Bombyx mori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.128 (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Bombyx mori the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.128 Bombyx mori C0SPF7
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.128 corpus allatum the enzyme specifically expressed in the corpus allatum, an endocrine organ that synthesizes and secretes juvenile hormones. CYP15C1 mRNA is constitutively expressed in corpus allatum from the first instar larval to adult stages, even when juvenile-hormone is not synthesized. No apparent differences in levels of CYP15C1 mRNA are observed between males and females during pupal and adult stages Bombyx mori
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.128 (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme, found in Lepidoptera (moths and butterflies), is specific for farnesoate. It is involved in the synthesis of juvenile hormone Bombyx mori juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
1.14.14.128 (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 the enzyme exhibits at least 18fold higher activity for farnesoate than (2E,6E)-methyl farnesoate Bombyx mori juvenile-hormone-III carboxylate + [oxidized NADPH-hemoprotein reductase] + H2O juvenile-hormone-III carboxylate i.e. (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyldodeca-2,6-dienoate ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.128 BGIBMGA011708
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 Bombyx mori
1.14.14.128 CYP15C1
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 Bombyx mori

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.128 cytochrome P-450 a heme-thiolate protein Bombyx mori

General Information

EC Number General Information Comment Organism
1.14.14.128 malfunction CYP15C1 is the gene responsible for the dimolting (mod) mutant that undergoes precocious metamorphosis with fewer larval–larval molt. A 68-bp deletion is identified in the mod allele that introduces a premature stop codon in the coding region of CYP15C1 Bombyx mori
1.14.14.128 metabolism the enzyme is involved in the synthesis of juvenile hormone Bombyx mori