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Literature summary extracted from

  • Minakuchi, C.; Ishii, F.; Washidu, Y.; Ichikawa, A.; Tanaka, T.; Miura, K.; Shinoda, T.
    Expressional and functional analysis of CYP15A1, a juvenile hormone epoxidase, in the red flour beetle Tribolium castaneum (2015), J. Insect Physiol., 80, 61-70.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.127 expression in Sf9 cells Tribolium castaneum

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.127 Tribolium castaneum D6WFY6
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.127 corpus allatum
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 Tribolium castaneum
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1.14.14.127 additional information level of CYP15A1 mRNA is high in the embryonic stage as well as in the middle of the final larval instar. In the embryonic stage, the transcript level of CYP15A1 starts to increase 30 h after egg laying and peaks 54-60 h after egg laying Tribolium castaneum
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.127 (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
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 Tribolium castaneum ? + [oxidized NADPH-hemoprotein reductase] + H2O
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 ?
1.14.14.127 methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
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 Tribolium castaneum juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O product has (10R)-configuration ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.127 CYP15A1
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 Tribolium castaneum

General Information

EC Number General Information Comment Organism
1.14.14.127 physiological function RNAi-mediated knockdown of CYP15A1 in the pre-final larval instar does not result in precocious metamorphosis to pupa. The double knockdown of juvenile hormone acid O-methyltransferase and TcCYP15A1 results in pupae and adults with shorter wings Tribolium castaneum