Literature summary extracted from
Brenndoerfer, E.D.; Brass, A.; Karthe, J.; Ahlen, G.; Bode, J.G.; Saellberg, M.
Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy (2014), J. Immunol., 192, 1671-1680.
Application
EC Number |
Application |
Comment |
Organism |
---|
3.4.21.98 |
medicine |
cleavage of T cell protein tyrosine phosphatase by NS3/4A induces a shift of the intrahepatic immune response toward a nonantiviral Th2-dominated immunity |
Hepacivirus C |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.4.21.98 |
ribavirin |
- |
Hepacivirus C |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.4.21.98 |
Hepacivirus C |
- |
- |
- |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
General Information
EC Number |
General Information |
Comment |
Organism |
---|
3.4.21.98 |
physiological function |
intrahepatic expression of viral protease NS3/4A makes mice resistant to TNF-alpha-induced liver damage and causes an alteration of the intrahepatic cytokine IFN-g and IL-10 and chemokine CCL3, CCL17, CCL22, CXCL9, and CXCL11 profiles toward an anti-inflammatory state. The number of intrahepatic Th1 cells and IFN-g+ T cells in NS3/4A transgenic mice decreases, whereas the amount of Th2 cells increases. The NS3/4A-mediated effects are reversed by ribavirin treatment |
Hepacivirus C |