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Literature summary extracted from

  • Grin, A.; Samaan, S.; Tripathi, M.; Rotondo, F.; Kovacs, K.; Bassily, M.N.; Yousef, G.M.
    Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma (2015), Hum. Pathol., 46, 541-548.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.B10 diagnostics enzyme KLK6 is significantly associated with other prognostic markers in gastroesophageal junction adenocarcinoma and Barrett esophagus, including depth of invasion, indicating its potential as independent biomarker Homo sapiens
3.4.21.B41 diagnostics enzyme KLK10 is significantly associated with other prognostic markers in gastroesophageal junction adenocarcinoma and Barrett esophagus, including depth of invasion, indicating its potential as independent biomarker Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B10 additional information the enzyme expression shows a granular cytoplasmic pattern of staining with luminal accentuation, immunohistochemic analysis, overview Homo sapiens
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Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B10 Homo sapiens Q92876 gene KLK6
-
3.4.21.B41 Homo sapiens O43240 KLK10
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B10 esophagus Barrett esophagus with and without dysplasia Homo sapiens
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3.4.21.B10 gastroesophageal junction adenocarcinoma cell early stage Homo sapiens
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3.4.21.B10 additional information significantly increased enzyme expression in early invasive cancer compared with dysplastic and nondysplastic Barrett esophagus, immunohistochemic analysis, overview Homo sapiens
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3.4.21.B41 colorectal cancer the enzyme is up-regulated in colorectal cancer Homo sapiens
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3.4.21.B41 esophagus Barrett esophagus with and without dysplasia Homo sapiens
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3.4.21.B41 gastroesophageal junction adenocarcinoma cell early stage Homo sapiens
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3.4.21.B41 additional information significantly increased enzyme expression in dysplastic lesions compared with metaplasia but not between dysplastic lesions and invasive cancers, immunohistochemic analysis, overview Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.4.21.B10 kallikrein-related peptidase 6
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 Homo sapiens
3.4.21.B10 KLK6
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 Homo sapiens
3.4.21.B41 KLK10
-
 Homo sapiens
3.4.21.B41 tissue kallikrein-related peptidase 10
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.B10 Homo sapiens stepwise expression increase from metaplasia to dysplasia and invasive tumors, significantly increased enzyme expression in early invasive cancer, overview up
3.4.21.B41 Homo sapiens the enzyme is up-regulated in colorectal cancer, stepwise expression increase from metaplasia to dysplasia and invasive tumors, significantly increased enzyme expression in early invasive cancer, overview up

General Information

EC Number General Information Comment Organism
3.4.21.B10 evolution the enzyme is a member of the human kallikrein gene family of secreted serine proteases Homo sapiens
3.4.21.B10 additional information significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect Homo sapiens
3.4.21.B41 evolution the enzyme is a member of the human kallikrein gene family of secreted serine proteases Homo sapiens
3.4.21.B41 additional information significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect Homo sapiens