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Literature summary extracted from
- Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity (2015), Biochim. Biophys. Acta, 1854, 73-83.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.35 | expressed in a baculovirus/insect cell line system | Homo sapiens |
| 3.4.21.117 | the gene encoding the enzyme is localized at chromosome locus 19q13.4, recombinant expression in an insect cell line using the baculovirus transfection system | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.35 | Abz-KDFSSKQ-EDDnp | - |
Homo sapiens |  |
| 3.4.21.35 | Abz-KEFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KGFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KHFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KIFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KKFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLASSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLDSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLESSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFESK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFHSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFISK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFKSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFLSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFNSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFPSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFSEKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFSFKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFSHKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFSPKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFSQKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLFVSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLGSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLHSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLISSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLKSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLLSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLMSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLNSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLPSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLQSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLRSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLSSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLTSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLVSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KLWSSK-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KMFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KNFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KQFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KRFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KSFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KTFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | Abz-KWFSSKQ-EDDnp | - |
Homo sapiens | |
| 3.4.21.35 | diglutamic acid | - |
Homo sapiens | |
| 3.4.21.35 | kallistatin | irreversible inhibitor | Homo sapiens | |
| 3.4.21.117 | Abz-KLASSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLDSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLESSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLGSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLHSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLISSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLKSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLLSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLMSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLNSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLPSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLQSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLRSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLSSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLTSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLVSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | Abz-KLWSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
Homo sapiens | |
| 3.4.21.117 | FEIIKKYQ | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.35 | 0.0006 | - |
Abz-KLFRSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0015 | - |
Abz-KLFSRKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0016 | - |
Abz-KLFFSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0016 | - |
Abz-KLFSSRQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0016 | - |
Abz-KLFSSGQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0017 | - |
Abz-NLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0018 | - |
Abz-KLFSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0018 | - |
Abz-KLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0019 | - |
Abz-KVFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0021 | - |
Abz-VLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0023 | - |
Abz-KLFSNKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0024 | - |
Abz-KLFWSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0025 | - |
Abz-KPFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-KLFTSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-KLFSIKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-KLFSVKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-KLFSGKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-KYFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0027 | - |
Abz-ILFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.003 | - |
Abz-KFFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0032 | - |
Abz-KLFSSLQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0032 | - |
Abz-KLFSSDQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0032 | - |
Abz-FLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0033 | - |
Abz-KLFSSIQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0034 | - |
Abz-KLYSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0034 | - |
Abz-HLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0035 | - |
Abz-KAFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0037 | - |
Abz-KLFSLKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0041 | - |
Abz-RLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0043 | - |
Abz-KLFSSQQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0043 | - |
Abz-ALFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0045 | - |
Abz-KLFSSNQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0046 | - |
Abz-LLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0052 | - |
Abz-QLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0059 | - |
Abz-KLFSSSQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0062 | - |
Abz-KLFSAKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0062 | - |
Abz-GLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0104 | - |
Abz-KLFSSVQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0127 | - |
Abz-KLFSSEQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0004 | - |
Abz-MISLMKRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0009 | - |
Abz-AIKFFSA-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0017 | - |
Abz-NLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0018 | - |
Abz-KLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0019 | - |
Abz-KVFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.002 | - |
Abz-GFSPFRSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0021 | - |
Abz-VLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0025 | - |
Abz-KPFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0027 | - |
Abz-KYFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0027 | - |
Abz-ILFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.003 | - |
Abz-KFFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0032 | - |
Abz-FLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0034 | - |
Abz-KLYSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0034 | - |
Abz-HLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0035 | - |
Abz-KAFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0041 | - |
Abz-RLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0043 | - |
Abz-ALFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0046 | - |
Abz-LLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0052 | - |
Abz-QLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0062 | - |
Abz-GLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.069 | - |
Abz-GFSPFRSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.117 | sodium chloride | inhibits the enzyme to over 60% at up to 1 M | Homo sapiens | |
| 3.4.21.117 | Sodium citrate | inhibits the enzyme at up to 750 mM, but not at higher concentrations | Homo sapiens | |
| 3.4.21.117 | Sodium sulfate | inhibits the enzyme at up to 1000 mM, but not at higher concentrations | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.35 | Homo sapiens | - |
- |
- |
| 3.4.21.117 | Homo sapiens | P49862 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.35 | central nervous system | - |
Homo sapiens | - |
| 3.4.21.35 | gastrointestinal tract | - |
Homo sapiens | - |
| 3.4.21.35 | skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.35 | Abz-ALFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-FLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-GLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-HLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-ILFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KAFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KFFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KLFFSK-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + FSK-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFRSK-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + RSK-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSAKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SAKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSGKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SGKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSIKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SIKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSLKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SLKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSNKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SNKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSRKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SRKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSDQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSDQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSEQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSEQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSGQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSGQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSIQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSIQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSK-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSK-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSLQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSLQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSNQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSNQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSQQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSQQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSRQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSRQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSSQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSSQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSSVQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SSVQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFSVKQ-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + SVKQ-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFTSK-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + TSK-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLFWSK-EDDnp + H2O | - |
Homo sapiens | Abz-KLF + WSK-EDDnp | - |
? | |
| 3.4.21.35 | Abz-KLYSSK-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KPFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KVFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-KYFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-LLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-MISLMKRPPGFSPFRSSRI-NH2 + H2O | - |
Homo sapiens | Abz-MISLM + KRPPGFSPF + RSSRI-NH2 | - |
? | |
| 3.4.21.35 | Abz-NLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-NLYRVE-Q-EDDnp + H2O | - |
Homo sapiens | Abz-NLY + RVE-Q-EDDnp | - |
? | |
| 3.4.21.35 | Abz-QLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-RLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Abz-VLFSSKQ-EDDnp + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | somatostatin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.35 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.117 | Abz-AIKFFSA-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-AIKFF + SA-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-ALFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-ALF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-FLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-FLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-GFSPFRSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-GFSPF + RSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-GFSPFRSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-GFSPF + RSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-GLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-GLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-HLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-HLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-ILFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-ILF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KAFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KAF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KFFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KFF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KLFSSE-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KLF + SSE-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KLTWLPL-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KLTW + LPL-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KLYSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KLY + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KPFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KPF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KVFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KVF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-KYFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-KYF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-LLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-LLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-LMEKWTW-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-LMEKW + TW-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-MISLMKRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-MISLM + KRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-NLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-NLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-PHVMRFP-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-PHVM + RFP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-QLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-QLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-RLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-RLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-VARPYYL-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-VARPYY + L-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-VLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-VLF + SSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-VQFYQGP-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-VQFY + QGP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-VQMRGFA-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-VQM + RGF + A-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-YNPFVFT-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-YNPF + VF + T-Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | Abz-YWSIQPF-Q-N-[2,4-dinitrophenyl]-ethylenediamine + H2O | - |
Homo sapiens | Abz-Y + WSIQPF + Q-N-[2,4-dinitrophenyl]-ethylenediamine | - |
? | |
| 3.4.21.117 | AGCKNFFWKTFTSC + H2O | - |
Homo sapiens | AGCKNFF + WKTFTSC | - |
? | |
| 3.4.21.117 | ATHPFIIQ + H2O | - |
Homo sapiens | ATHPF + IIQ | - |
? | |
| 3.4.21.117 | DYEAGGY + H2O | - |
Homo sapiens | L-Asp-L-Tyr + EAGGY | - |
? | |
| 3.4.21.117 | GNYDGPD + H2O | - |
Homo sapiens | GNY + DGPD | - |
? | |
| 3.4.21.117 | GVRPHGF + H2O | - |
Homo sapiens | GV + RPHGF | - |
? | |
| 3.4.21.117 | kallistatin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.117 | LMQHPQD + H2O | - |
Homo sapiens | LM + QHPQD | - |
? | |
| 3.4.21.117 | additional information | the P3-P'3' sequence NLYRVR is identified as a preferred substrate for the enzyme, glutamate at position P3' is also well accepted, substrate specificity, overview. No activity with Abz-KVYFFFRENAI-Q-N-[2,4-dinitrophenyl]-ethylenediamine. Kininogenase activity of the enzyme using as substrate a synthetic peptide derived from human kininogen (Abz-MISLMKRPPGFSPFRSSRI-NH2) containing the amino acids F and M as two possible cleavage site | Homo sapiens | ? | - |
? | |
| 3.4.21.117 | PDETYFF + H2O | - |
Homo sapiens | PDETY + L-Phe-L-Phe | - |
? | |
| 3.4.21.117 | QMELPVH + H2O | - |
Homo sapiens | Gln-Met + ELPVH | - |
? | |
| 3.4.21.117 | RPKPQQFFGLM + H2O | - |
Homo sapiens | RPKPQQ + L-Phe + FGLM | - |
? | |
| 3.4.21.117 | SANSNPAMAPRERKAGCKNFFWKTFTSC + H2O | - |
Homo sapiens | SANSNPAMAPRERKAGCKNFF + WKTFTSC | - |
? | |
| 3.4.21.117 | SFPQVHS + H2O | - |
Homo sapiens | SFPQV + L-His-L-Ser | - |
? | |
| 3.4.21.117 | somatostatin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.117 | STLDWQD + H2O | - |
Homo sapiens | STLDW + QD | - |
? | |
| 3.4.21.117 | STLDWQH + H2O | - |
Homo sapiens | STLDW + QH | - |
? | |
| 3.4.21.117 | Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.117 | TGQPIGI + H2O | - |
Homo sapiens | TGQPI + Gly-L-Ile | - |
? | |
| 3.4.21.117 | VQPFHDP + H2O | - |
Homo sapiens | VQPF + HDP | - |
? | |
| 3.4.21.117 | VREHMVD + H2O | - |
Homo sapiens | VREHM + L-Val-L-Asp | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.35 | kallikrein-related peptidase 7 | - |
Homo sapiens |
| 3.4.21.35 | KLK7 | - |
Homo sapiens |
| 3.4.21.117 | kallikrein-related peptidase 7 | - |
Homo sapiens |
| 3.4.21.117 | KLK7 | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 25 | 37 | assay at | Homo sapiens |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.35 | 0.02 | - |
Abz-KLFSSIQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.02 | - |
Abz-KYFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.02 | - |
Abz-KFFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.02 | - |
Abz-KAFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.02 | - |
Abz-KPFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.03 | - |
Abz-GLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFRSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFFSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFTSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFWSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFSNKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KLFSGKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.04 | - |
Abz-KVFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.05 | - |
Abz-KLFSSDQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.06 | - |
Abz-KLFSSVQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.06 | - |
Abz-ILFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.07 | - |
Abz-KLFSSNQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.07 | - |
Abz-LLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.08 | - |
Abz-KLFSSLQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.09 | - |
Abz-KLFSIKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.09 | - |
Abz-KLFSSGQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.09 | - |
Abz-FLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.1 | - |
Abz-KLFSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.1 | - |
Abz-KLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.1 | - |
Abz-ALFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.1 | - |
Abz-HLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.13 | - |
Abz-VLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.13 | - |
Abz-RLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.14 | - |
Abz-KLFSSQQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.15 | - |
Abz-KLFSRKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.15 | - |
Abz-KLFSLKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.15 | - |
Abz-QLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.17 | - |
Abz-KLFSSRQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.28 | - |
Abz-NLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.35 | - |
Abz-KLFSVKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.43 | - |
Abz-KLFSAKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.43 | - |
Abz-KLFSSSQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.5 | - |
Abz-KLFSSEQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.85 | - |
Abz-KLYSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.117 | 0.01 | - |
Abz-MISLMKRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.02 | - |
Abz-KYFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.02 | - |
Abz-KFFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.02 | - |
Abz-KAFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.02 | - |
Abz-KPFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.03 | - |
Abz-AIKFFSA-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.03 | - |
Abz-GLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.03 | - |
Abz-GFSPFRSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.04 | - |
Abz-KVFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.06 | - |
Abz-ILFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.07 | - |
Abz-LLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.09 | - |
Abz-FLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.1 | - |
Abz-KLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.1 | - |
Abz-ALFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.1 | - |
Abz-HLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.13 | - |
Abz-VLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.13 | - |
Abz-RLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.15 | - |
Abz-QLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.28 | - |
Abz-NLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.85 | - |
Abz-KLYSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 1 | - |
Abz-GFSPFRSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.117 | 7.5 | - |
assay at | Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.35 | 0.0000068 | - |
kallistatin | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0002 | - |
Abz-KLISSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0003 | - |
Abz-KLKSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0005 | - |
Abz-KIFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0006 | - |
Abz-KLFKSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0006 | - |
Abz-KQFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0007 | - |
Abz-KTFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0009 | - |
Abz-KLFSQKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0009 | - |
Abz-KMFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0009 | - |
Abz-KWFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.001 | - |
Abz-KLMSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.001 | - |
Abz-KLWSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0011 | - |
Abz-KLNSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0011 | - |
Abz-KRFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0012 | - |
Abz-KKFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0012 | - |
Abz-KHFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0013 | - |
Abz-KLHSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0014 | - |
Abz-KLFLSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0014 | - |
Abz-KLFISK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0014 | - |
Abz-KLFPSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0014 | - |
Abz-KLFSHKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0015 | - |
Abz-KLLSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0016 | - |
Abz-KLRSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0017 | - |
Abz-KLFVSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0017 | - |
Abz-KLVSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0018 | - |
Abz-KLSSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.002 | - |
Abz-KLASSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0022 | - |
Abz-KLPSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0022 | - |
Abz-KLGSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0022 | - |
Abz-KLQSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0023 | - |
Abz-KLTSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0026 | - |
Abz-KGFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.003 | - |
Abz-KLESSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.003 | - |
Abz-KDFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0032 | - |
Abz-KLDSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0035 | - |
Abz-KEFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0041 | - |
Abz-KNFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0047 | - |
Abz-KLFESK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0048 | - |
Abz-KLFSPKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0052 | - |
Abz-KSFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0061 | - |
Abz-KLFSEKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0083 | - |
Abz-KLFNSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.0096 | - |
Abz-KLFSFKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 0.018 | - |
Abz-KLFHSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 33 | - |
diglutamic acid | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0002 | - |
Abz-KLISSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0003 | - |
Abz-KLKSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.001 | - |
Abz-KLMSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.001 | - |
Abz-KLWSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0011 | - |
Abz-KLNSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0013 | - |
Abz-KLHSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0015 | - |
Abz-KLLSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0016 | - |
Abz-KLRSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0017 | - |
Abz-KLVSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0018 | - |
Abz-KLSSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.002 | - |
Abz-KLASSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0022 | - |
Abz-KLPSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0022 | - |
Abz-KLGSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0022 | - |
Abz-KLQSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0023 | - |
Abz-KLTSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.003 | - |
Abz-KLESSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 0.0032 | - |
Abz-KLDSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.117 | evolution | human kallikrein-related peptidase 7 is one member from a cluster of 15 serine peptidases of the chymotrypsin-like S1A family clan PA(S) sharing a high degree of identity and localized at human chromosome locus 19q13.4 | Homo sapiens |
| 3.4.21.117 | physiological function | the enzyme plays roles in physiological and pathological skin desquamation processes that requires the presence of water in the stratum corneum, which is maintained by hygroscopic compounds collectively named as skin moisturizing factor | Homo sapiens |
kcat/KM [mM/s]
| EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.35 | 5 | - |
Abz-GLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 5.7 | - |
Abz-KFFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 6 | - |
Abz-KLFSSIQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 6 | - |
Abz-KLFSSVQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 6 | - |
Abz-KYFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 6.3 | - |
Abz-KAFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 6.4 | - |
Abz-KPFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 15 | - |
Abz-KLFTSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 15 | - |
Abz-KLFSGKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 15 | - |
Abz-LLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 16 | - |
Abz-KLFSNKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 16 | - |
Abz-KLFSSNQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 16 | - |
Abz-KLFSSDQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 17 | - |
Abz-KLFWSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 20 | - |
Abz-KVFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 21 | - |
Abz-ILFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 22 | - |
Abz-ALFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 25 | - |
Abz-KLFFSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 25 | - |
Abz-KLFSSLQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 27 | - |
Abz-FLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 29 | - |
Abz-QLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 30 | - |
Abz-HLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 31 | - |
Abz-KLFSIKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 32 | - |
Abz-RLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 33 | - |
Abz-KLFSSQQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 39 | - |
Abz-KLFSSEQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 41 | - |
Abz-KLFSLKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 47 | - |
Abz-KLFRSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 53 | - |
Abz-KLFSSGQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 55 | - |
Abz-KLFSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 55 | - |
Abz-KLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 62 | - |
Abz-VLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 69 | - |
Abz-KLFSAKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 73 | - |
Abz-KLFSSSQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 100 | - |
Abz-KLFSRKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 106 | - |
Abz-KLFSSRQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 130 | - |
Abz-KLFSVKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 165 | - |
Abz-NLFSSKQ-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.35 | 250 | - |
Abz-KLYSSK-EDDnp | at pH 7.5 and 37°C | Homo sapiens | |
| 3.4.21.117 | 5 | - |
Abz-GLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 5.7 | - |
Abz-KFFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 6 | - |
Abz-KYFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 6.3 | - |
Abz-KAFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 6.4 | - |
Abz-KPFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 13 | - |
Abz-GFSPFRSSRI-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 14 | - |
Abz-GFSPFRSSRIGEIKEETT-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 15 | - |
Abz-LLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 20 | - |
Abz-KVFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 21 | - |
Abz-ILFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 22 | - |
Abz-ALFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 23 | - |
Abz-MISLMKRP-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 27 | - |
Abz-FLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 29 | - |
Abz-AIKFFSA-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 29 | - |
Abz-QLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 30 | - |
Abz-HLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 32 | - |
Abz-RLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 55 | - |
Abz-KLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 62 | - |
Abz-VLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 165 | - |
Abz-NLFSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
| 3.4.21.117 | 250 | - |
Abz-KLYSSK-Q-N-[2,4-dinitrophenyl]-ethylenediamine | pH 7.5, 37°C | Homo sapiens | |
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Release 2023.1 (January 2023)
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