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Literature summary extracted from

  • Choi, K.; Joo, H.; Campbell, J.L.; Andersen, M.E.; Clewell, H.J.
    In vitro intestinal and hepatic metabolism of di(2-ethylhexyl) phthalate (DEHP) in human and rat (2013), Toxicol. In Vitro, 27, 1451-1457.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.60 cytosol
-
 Homo sapiens 5829
-
3.1.1.60 cytosol
-
 Rattus norvegicus 5829
-
3.1.1.60 microsome
-
 Homo sapiens
-
-
3.1.1.60 microsome higher enzyme activity compared to cytosol Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.60 bis(2-ethylhexyl)phthalate + H2O Homo sapiens
-
 2-ethylhexyl phthalate + 2-ethylhexan-1-ol
-
 ?
3.1.1.60 bis(2-ethylhexyl)phthalate + H2O Rattus norvegicus
-
 2-ethylhexyl phthalate + 2-ethylhexan-1-ol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.60 Homo sapiens
-
-
-
3.1.1.60 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.60 intestine
-
 Homo sapiens
-
3.1.1.60 intestine
-
 Rattus norvegicus
-
3.1.1.60 liver
-
 Homo sapiens
-
3.1.1.60 liver
-
 Rattus norvegicus
-
3.1.1.60 additional information enzyme activity in human intestine is 2.4fold higher than that in human liver Homo sapiens
-
3.1.1.60 additional information enzyme activity in rat intestine is 1.7fold less than that in rat liver Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.60 bis(2-ethylhexyl)phthalate + H2O
-
 Homo sapiens 2-ethylhexyl phthalate + 2-ethylhexan-1-ol
-
 ?
3.1.1.60 bis(2-ethylhexyl)phthalate + H2O
-
 Rattus norvegicus 2-ethylhexyl phthalate + 2-ethylhexan-1-ol
-
 ?

General Information

EC Number General Information Comment Organism
3.1.1.60 evolution an esterase-mediated pathway in rat liver might occur predominantly rather than in human liver although it is comparable between human and rat Homo sapiens
3.1.1.60 evolution an esterase-mediated pathway in rat liver might occur predominantly rather than in human liver although it is comparable between human and rat Rattus norvegicus
3.1.1.60 metabolism an esterase-mediated pathway in rat liver might occur predominantly rather than in human liver although it is comparable between human and rat Homo sapiens
3.1.1.60 metabolism an esterase-mediated pathway in rat liver might occur predominantly rather than in human liver although it is comparable between human and rat Rattus norvegicus