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Literature summary extracted from

  • Acharya, J.; Dubey, D.K.; Srivastava, A.K.; Raza, S.K.
    In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers (2011), Toxicol. In Vitro, 25, 251-256.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.7 2-PAM 34% reactivation of enzyme inhibited by sarin at 1 mM within 10 min Homo sapiens
3.1.1.7 N,N'-4-xylene-bis-[(2,2'-hydroxyiminomethyl)pyridinium] dibromide most potent reactivator for enzyme inhibited by sarin (45% regeneration at 1 mM within 10 min) Homo sapiens
3.1.1.7 N,N'-4-xylene-bis[(3,3'-hydroxyiminomethyl)-pyridinium] dibromide 33% reactivation of enzyme inhibited by sarin at 1 mM within 10 min Homo sapiens
3.1.1.7 obidoxime 24% reactivation of enzyme inhibited by sarin at 1 mM within 10 min Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 sarin
-
 Homo sapiens
3.1.1.7 soman
-
 Homo sapiens
3.1.1.7 Tabun
-
 Homo sapiens
3.1.1.7 VX
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.7 acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens