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Literature summary extracted from

  • Beck, C.; Morse, R.; Cunningham, D.; Iniguez, A.; Low, D.; Goulding, C.; Hayes, C.
    CdiA from enterobacter cloacae delivers a toxic ribosomal RNase into target bacteria (2014), Structure, 22, 707-718.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.21 cloning of cdiA-CTECL under the control of an arabinose-inducible promoter and expression in Escherichia coli, which leads to growth inhibition of the bacterial cells Enterobacter cloacae

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.21 additional information CdiA-CT toxins are specifically neutralized by cognate CdiI immunity proteins to protect toxin-producing cells from autoinhibition Enterobacter cloacae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.21 additional information Enterobacter cloacae the CdiA-CTECL toxin has 16S rRNase activity ?
-
 ?
4.6.1.21 additional information Enterobacter cloacae ATCC 13047 the CdiA-CTECL toxin has 16S rRNase activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.21 Enterobacter cloacae
-
-
-
4.6.1.21 Enterobacter cloacae ATCC 13047
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.21 additional information the CdiA-CTECL toxin has 16S rRNase activity Enterobacter cloacae ?
-
 ?
4.6.1.21 additional information the CdiA-CTECL toxin has 16S rRNase activity Enterobacter cloacae ATCC 13047 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.21 CdiA-CT toxin
-
 Enterobacter cloacae

General Information

EC Number General Information Comment Organism
4.6.1.21 additional information the three-dimensional structure of enzyme CdiA-CTECL reveals similarity to the C-terminal nuclease domain of colicin E3. The resolved C-terminal domain of enzyme CdiA-CTECL consists of an N-terminal alpha helix, followed by a twisted five-stranded antiparallel beta sheet. The domain contains two long loops, L2 and L4, which connect beta1 to beta2 and beta3 to beta4, respectively Enterobacter cloacae
4.6.1.21 physiological function the 16S rRNase enzyme is a contact-dependent growth inhibition toxin unvolved in inter-bacterial competition. CdiA-CTECL cleaves 16S rRNA in vivo to inhibit cell growth, overview Enterobacter cloacae