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Literature summary extracted from

  • Bonardi, D.; Papini, N.; Pasini, M.; Dileo, L.; Orizio, F.; Monti, E.; Caimi, L.; Venerando, B.; Bresciani, R.
    Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation (2014), PLoS ONE, 9, e99405.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.18 cell surface
-
 Homo sapiens 9986
-
3.2.1.18 endosome
-
 Homo sapiens 5768
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.18 ganglioside GD1a + H2O Homo sapiens
-
 ?
-
 ?
3.2.1.18 ganglioside GM1 + H2O Homo sapiens
-
 ?
-
 ?
3.2.1.18 ganglioside GM3 + H2O Homo sapiens
-
 ?
-
 ?
3.2.1.18 lactosyl-ceramide + H2O Homo sapiens
-
 ?
-
 ?
3.2.1.18 additional information Homo sapiens sialidase NEU3 shows high enzymatic specificity toward gangliosides ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Homo sapiens Q9UQ49
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Homo sapiens 4-methylumbelliferone + N-acetylneuraminic acid
-
 ?
3.2.1.18 ganglioside GD1a + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 ganglioside GM1 + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 ganglioside GM3 + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 lactosyl-ceramide + H2O
-
 Homo sapiens ?
-
 ?
3.2.1.18 additional information sialidase NEU3 shows high enzymatic specificity toward gangliosides Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 Neu3
-
 Homo sapiens
3.2.1.18 sialidase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.2.1.18 metabolism NEU3 regulates the detergent resistant membranes ganglioside content and is as a modulator of Akt phosphorylation Homo sapiens